Cortisol and Aldosterone Synthesis – Adrenal Cortex

by Carlo Raj, MD

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    Here, we’ll go into a little bit more detail with cortisol and aldosterone synthesis, we’ll begin with cortisol synthesis. Here we have cortisol synthesis. Cortisol synthesis, you should be jumping directly into the middle layer which is the fasciculata. Here, we have a fasciculata cell, the adrenal cortex and I want you to begin on the left, you’ll notice that we have ATP being converted into cyclic AMP. So, therefore, this is ACTH binding to a receptor converting ATP into cyclic AMP. Cyclic AMP has a number of pathways that it’s going to then follow; the pathway here for cyclic AMP responsible for your LDL. Remember, what are we trying to form here? We’re trying to form cortisol and anytime you form cortisol, you must begin with cholesterol, right? How do you bring in cholesterol into the cell? LDL receptors. So, here’s LDL receptors with the help of cyclic AMP allows you to then endocytosis. Your LDL and cholesterol and then you begin the process. Your cholesterol will be converted into pregnenolone and that is your rate limiting enzyme and what is that please? Desmolase. So, if you want, make sure you go back and take a look and then with the middle layer, remember it’s 17 hydroxy. Alright, so, 17 hydroxypregnenolone, 17 hydroxyprogesterone, so on and so forth and ultimately, all of these cortisols are being secreted into your blood and that’s what you’re seeing on the-on the right there and your-your cortisol will then go to the respective organ maybe the liver and such. And then with the help of glucagon may then begin the process of gluconeogenesis. Cortisol synthesis, number one, ACTH bind to receptor cyclic AMP. Cyclic AMP allows for LDL to come into the cell. This LDL then delivers the cholesterol, it’s necessary for your...

    About the Lecture

    The lecture Cortisol and Aldosterone Synthesis – Adrenal Cortex by Carlo Raj, MD is from the course Adrenal Gland Disorders.

    Included Quiz Questions

    1. Cholesterol to pregnenolone
    2. LDL to cholesterol
    3. Pregnenolone to cortisol
    4. LDL to Pregnenolone
    5. Cholesterol to cortisol
    1. LDL will not be endocytosed into the cell
    2. ACTH will not bind to the receptor
    3. Cholesterol will not be freed from LDL
    4. Desmolase will not be formed
    5. Pregnenolone will not be formed
    1. Stimulated by potassium ions
    2. Present only in glomerulosa cells
    3. Stimulated by angiotensin II
    4. Converts corticosterone to aldosterone
    5. Necessary enzyme for the formation of aldosterone
    1. More formation of pregnenolone from cholesterol
    2. Less angiotensin II formation and release
    3. Less formation of aldosterone from corticosterone
    4. Negative effects on IP3 mechanism
    5. Less cholesterol freed from LDL

    Author of lecture Cortisol and Aldosterone Synthesis – Adrenal Cortex

     Carlo Raj, MD

    Carlo Raj, MD

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