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About the Lecture
The lecture Chemokines – Lymphocyte Recirculation and Homing by Peter Delves, PhD is from the course Adaptive Immune System.
Included Quiz Questions
To which chemokine family does RANTES belong?
- CC
- C
- CXC
- CX3C
- CCL5
Chemokine families are grouped according to their arrangement of cysteines and bond types, which of the following is the best description of this naming process?
- C denotes a cysteine-cysteine bond, X denotes an amino acid between adjacent cysteine bonds.
- C denotes a carbon-carbon bond, X denotes an amino acid between adjacent carbon bonds.
- C denotes a cysteine-cysteine bond, X denotes a carbon between adjacent cysteine bonds.
- C denotes a cysteine-amino acid bond, X denotes an amino acid between adjacent cysteine-amino acid bonds.
Migration of lymphocytes toward a recognized antigen is partially mediated by recognizing a chemokine gradient. How is this accomplished by the lymphocyte?
- A 7 transmembrane receptor is linked to a G-protein complex which activates the cell, moving it towards the higher concentrations of chemokines.
- The chemokine receptor on the lymphocyte depolarizes rapidly, allowing for a more intense response in a higher concentration gradient.
- A 7 transmembrane receptor slows the response of the lymphocyte, moving it down the chemokine concentration gradient.
- The lymphocyte irreversibly attaches to chemokines and uses diffusion to move down the concentration gradient.
- The chemokines stimulate a transmembrane G protein in the lymphocytes, inactivating the cell.
Author of lecture Chemokines – Lymphocyte Recirculation and Homing
Peter Delves, PhD
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