Celiac Disease

by Peter Delves, PhD

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    00:01 Let’s now look at celiac disease, yet another example where autoimmune reactions result in pathology.

    00:09 In celiac disease, there is T-cell reactivity to the gliadin component of wheat gluten in the small intestine.

    00:17 Gluten that is absorbed from the gut is taken up by dendritic cells.

    00:23 It is processed and presented to T-cells in the mesenteric lymph nodes.

    00:30 The cytokine interleukin-15 stimulates dendritic cells to go on and activate proinflammatory T-helper cells which secrete IL-21 and gamma interferon.

    00:44 There is an induction of gluten specific helper T-cells and B-cells.

    00:50 The lymphocytes home to the gut lamina propria.

    00:53 IL-15 also induces expression of the cytotoxicity-activating receptor NKG2D on CD8+ intraepithelial lymphocytes.

    01:06 The NKG2D recognizes stress-induced self ligands such as MICA and MICB.

    01:15 The NKG2D+ CD8+ intraepithelial lymphocytes destroy gut epithelial cells, resulting in celiac disease.

    01:29 In addition, autoantibodies against transglutaminase 2 (TG2) are present.

    01:36 Gluten binds to TG2.

    01:41 Therefore, IgA+ B-cells specific for TG2 may process and present the gliadin component of gluten to the T-helper cells.

    01:54 Again, contributing to pathology.

    About the Lecture

    The lecture Celiac Disease by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease.

    Included Quiz Questions

    1. Gliadin
    2. Keratin
    3. Elastin
    4. Albumin
    5. Catenin
    1. Anti-tissue transglutaminase
    2. Anti-double strand DNA
    3. Anti–cyclic citrullinated peptide
    4. Anti-Ro
    5. Anti-topoisomerase I

    Author of lecture Celiac Disease

     Peter Delves, PhD

    Peter Delves, PhD

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