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Bone Remodeling

by Thad Wilson, PhD
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    Bone remodeling. This is probably our most important clinical aspect of bone. Bone will remodel to three primary things. One is bone microdamage, which we’ll use in your example. Stress on the bone will also cause bone remodeling. And what do I mean by stress? It simply has to have the amount of torque on the bone. The other one that can do bone remodeling are hormones: parathyroid hormone and calcitonin. Let’s now move to our example of bone microdamage causing remodeling. The first thing that happens is this bone microdamage is sensed by osteocytes. Osteocytes are located deeper within the bone and these structures or cells will sense the microdamage has occurred. They then signal another cell known as bone lining cells. It is this bone lining cells that get the process started of remodeling. They will recruit osteoclasts, and osteoclasts are the type of bone cell that break down current bone. We then get bone reabsorption occurring and recruit osteoblasts to that particular area. Osteoblasts lay down new bone. Once that new bone is deposited or laid down, what happens to those osteoblasts? They can either be trapped within the bone and become osteocytes or they turn into bone lining cells. So this is the process that we’re going to step through. Now let’s take each one of these processes in greater detail so we understand the mechanisms behind bone remodeling which is so important for us clinically. The first step that we’ll review here is what happens to the initial signal. Remember, osteocytes need to signal bone lining cells. How does it do that? Well, it senses that there might have been microdamage that has occurred. This microdamage oftentimes sense these osteocytes into apoptosis, which is a programmed cell death of the osteocyte. The bone lining cells...

    About the Lecture

    The lecture Bone Remodeling by Thad Wilson, PhD is from the course Musculoskeletal Physiology.


    Included Quiz Questions

    1. Osteoclasts
    2. Osteocytes
    3. Osteoblasts
    4. Osteons
    1. Circadian rhythm
    2. Stress on the bone
    3. Hormones
    4. Microfractures

    Author of lecture Bone Remodeling

     Thad Wilson, PhD

    Thad Wilson, PhD


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    Good for a review.
    By Lucas S. on 24. April 2017 for Bone Remodeling

    In my opinion, this course on muscles is good for a review of the most important points of the topic. I couldn't find the striated muscle lecture, there are only smooth muscle lectures here. I think a little bit of more detail could make this course perfect!