Blood Transfusion

by Peter Delves, PhD

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    00:01 As I just mentioned, blood transfusion is the most common type of transplant.

    00:05 And here we can see the way in which the blood group antigens are inherited looking at the ABO blood groups.

    00:15 So here we have a father who is blood group A and a mother who is blood group B.

    00:21 The first child inherits the null allele from the father and from the mother, and therefore is blood group O.

    00:31 And they will produce natural antibodies against both blood group A and blood group B, because those are not antigens which are part of their body makeup.

    00:42 They will not be immunologically tolerant to those antigens.

    00:46 And structures that are very similar to those particular antigens are present on many common microbes.

    00:52 So we produce lots of natural antibodies against the A and B antigens if we lack those antigens ourselves.

    01:01 And this individual being blood group O will be a universal donor.

    01:08 Their second child has inherited the A blood group from the father and the null allele from the mother.

    01:17 And will be blood group A, and will produce B blood group specific antibodies.

    01:25 The third child is blood group B, having inherited B from the mother and the null allele from the father, and produces blood group A antibodies from birth.

    01:38 And then child four is AB blood group.

    01:43 And because both the A blood group and the B blood group are now self antigens for this individual, they do not produce antibodies against either blood group A or blood group B antigens, and will be a universal recipient.

    About the Lecture

    The lecture Blood Transfusion by Peter Delves, PhD is from the course Transplantation Immunology.

    Included Quiz Questions

    1. Natural antibodies
    2. Only specific for human red blood cells
    3. Specific for protein antigens
    4. Only present in adults
    5. Largely responsible for the rejection of a kidney allograft
    1. Molecular mimicry with common microbes
    2. Exposure to A and B blood
    3. Genetic predisposition to reject A and B blood
    4. Inheritance - one parent must be type B or A
    5. Fetal exposure to microbes results in overproduction of A and B antibodies

    Author of lecture Blood Transfusion

     Peter Delves, PhD

    Peter Delves, PhD

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