Asthma Medication Questions

00:01 Let's do some questions. Which of the following are bronchodilators? Prednisone, cromolyn, theophylline, omalizumab, and montelukast.

00:06 Let's do some questions. Which of the following are bronchodilators? Prednisone, cromolyn, theophylline, omalizumab, and montelukast.

00:18 Good, theophylline. Remember that prednisone is a steroid, it is an anti-inflammatory agent, it does not cause bronchodilation.

00:26 Cromolyn is a mast cell degranulation inhibitor or a release inhibitor.

00:31 Omalizumab is a IgE mediated monoclonal antibody and montelukast is a leukotriene antagonist.

00:41 Pick the false statement.

00:44 Zileuton selectively inhibits lipoxygenase. LT antagonists or LTAs are effective in acute asthma episodes.

00:52 LTAs are effective in antigen induced bronchospasm. LT agonists have low toxicity.

00:59 And montelukast is an antagonist of the LTD4 receptor.

01:06 The false statement is that LT antagonists are effective in acute asthma episodes.

01:11 Remember that we do not want to use this medication in acute asthma, we want to use it in chronic asthma and it maintains stability.

01:20 Let's move on to the next question, corticosteroids. So finish the sentence.

01:27 Corticosteroids reduce the synthesis of arachidonic acid by folic acid reduction.

01:33 B, corticosteroids increase the expression of COX-2.

01:38 C, corticosteroids inhibit phospholipase A2 activity to reduce arachidonic acid levels.

01:46 D, inhaled corticosteroids are rarely used due to systemic side effects.

01:50 And E, prednisone is commonly used in chronic mild asthma.

01:58 Right, corticosteroids inhibit phospholipase A2 activity to reduce arachidonic acid levels.

02:06 Well, there you have it. That's our respiratory lecture. I hope you enjoyed it, I hope you learned something.

02:11 Good luck on your exams. I'm sure you're going to do really well.