by Pravin Shukle, MD

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    Let's start off with looking at a platelet. So, a platelet is a very important part of a blood clot, it's like the brick in the wall. And platelets, if they don't adhere to each other, aren't going to form very good clots for us. So the glycoprotein IIb/IIIa molecule is central to the function of a platelet. You can see here, I have a picture of a platelet next to me. And you can see in blue, the glycoprotein IIb/IIIa molecule which is also called the alpha IIb beta 3 molecule in Europe allows that platelet to adhere to the collagen substrate of any particular tissue. The other thing that this glycoprotein IIb/IIIa molecule allows us to do is adhere to other platelets so you can see that there is another platelet attaching to the first platelet through fibronogen. This cross linking and activation of platelet adhesion and aggregation are important components of the glycoprotein IIb/IIIa molecule. The third component of platelet function is its release function. Now, thromboxane A2 place a very important component in the release function. ADP is released when platelets bind to damaged tissue. And ADP is another important component in platelet function. This brings us to our first drug, aspirin. Aspirin is an irreversible inhibitor of cylooxygenase. It is used to manufacture thromboxane A2. And platelets, when you inhibit cyclooxygenase with aspirin, actually are permanently inhibited. That means that the antiplatelet function of aspirin is going to last for the entire life of this platelet, and that means that only replacement platelets will be functional, and that means that the aspirin is going to last anywhere between 3 and 7 days. Interactions of aspirin are very important because the aspirin is going to interact with non-steroidal anti-inflammatory pain agents. They impair platelet functions on...

    About the Lecture

    The lecture Antiplatelets by Pravin Shukle, MD is from the course Pharmacology of Blood Coagulation. It contains the following chapters:

    • Antiplatelets: Looking at a Platelet
    • Antiplatelets: Aspirin
    • Antiplatelets: Glycoprotein Inhibitors
    • Antiplatelets: ADP Inhibitors
    • Antiplatelets: PDE/Adenosine Uptake Inhibitors
    • Antiplatelets: Uses
    • Antiplatelets: Toxicity

    Included Quiz Questions

    1. ADP
    2. GPIIb/IIIa
    3. Alpha granule
    4. Dense granule
    5. Fibrinogen
    1. Cilostazol
    2. Dipyridamole
    3. Aspirin
    4. Eptifibatide
    5. Clopidogrel
    1. Eptifibatide
    2. Clopidogrel
    3. All of the answers are irreversible.
    4. Aspirin
    5. Prasugrel
    1. All of the answers would be expected.
    2. Increase in platelet cAMP levels.
    3. Inhibition of phosphodiesterase.
    4. Increased activation of A2 receptor on platelet surface.
    5. Increase in plasma concentration of adenosine.

    Author of lecture Antiplatelets

     Pravin Shukle, MD

    Pravin Shukle, MD

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