Overview – Antimycobacterial Agents

by Pravin Shukle, MD

My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides AntimycobacterialAgents Antimicrobials.pdf
    • PDF
      Download Lecture Overview
    Report mistake

    00:01 Welcome to pharmacology by Lecturio.

    00:04 We're going to continue our discussion about antibiotics by talking about some unique antibacterials.

    00:09 These are a list of the different categories that we have covered so far.

    00:13 The last group are the drugs that will really cover mycobacterial infections that includes tuberculosis, leprosy, and other types of infections like Mycobacterium avium.

    00:24 In terms of the anti-TB drugs or anti-mycobacterial agents will really focus on some of the tuberculous agents as individual drugs and not focus so much today on the therapies that are usually used in combination.

    00:40 Now, tuberculosis agents can either be bacteriostatic, or bactericidal.

    00:45 What does that mean? First of all, bacteriostatic means that you just stop the replication of bacteria.

    00:51 You're not actually killing them.

    00:53 what you're doing is you're allowing the immune system to catch up to those numbers, so that the immune system can take care of those live bacteria left.

    01:01 Bactericidal actually refers to the death of bacteria.

    01:05 In this case, the antibacterial agent is killing the bacterium.

    01:10 Now, when we talk about tuberculosis, we usually talk about using them in three or four drug combinations.

    01:17 In most disease states, we try to use one or two drugs to treat a particular disease.

    01:22 But in tuberculosis, it's so hard to treat that we actually will need to combine different agents from different drug classes to get a full resolution and treatment of the disease.

    01:34 Sometimes will even go as far as to directly observe the therapies.

    01:39 So I saw this happen myself when I was practicing in rural Canada on the Prairies, and in northern communities, where patients may not be as, say, adherent to the regimen as we would like.

    01:53 In those cases, whether it's due to other diseases that are taking part or due to social reasons, we have to actually watch patients take the medications.

    02:02 If we don't have directly observed therapy, and if there's any kind of a reduction in adherence to therapy, the therapy just doesn't work.

    02:10 That's why DOT regimens in tuberculosis are so important.

    02:14 Now, you can see here I have an image.

    02:17 It's a close up image of a mycobacterium tuberculosis culture.

    About the Lecture

    The lecture Overview – Antimycobacterial Agents by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. Requires single-drug therapy for effective treatment
    2. Patients must be monitored for significant side effects of treatment.
    3. Drugs may be bacteriostatic or bactericidal, depending on concentration.
    4. They are usually administered via DOT regimens (directly observed therapy).
    5. These drugs are bacteriostatic or bactericidal, depending upon the concentration.

    Author of lecture Overview – Antimycobacterial Agents

     Pravin Shukle, MD

    Pravin Shukle, MD

    Customer reviews

    5,0 of 5 stars
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1  Star