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Aminoglycosides – Bacterial Protein Synthesis Inhibitors (Antibiotics)

by Pravin Shukle, MD
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    The lecture Aminoglycosides – Bacterial Protein Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Included Quiz Questions

    1. Block transcription on the 50S subunit.
    2. Prevents the initiation complex from forming.
    3. Incorporated into the bacteria through an oxygen dependent process.
    4. Inhibits translocation from mRNA.
    5. Causes misread errors in the mRNA.
    1. They are usually administered in multidose regimens.
    2. They must be given intravenously or intramuscularly.
    3. They exhibit strong post-antibiotic activity allowing low trough levels.
    4. Drug levels must be monitored using peak/trough levels to ensure concentration dependent killing action.
    5. Dosing depends on renal function.
    1. Nephrotoxicity is decreased with administration of amphotericin B.
    2. Tobramycin is associated with vestibular ototoxicity.
    3. Amikacin may be associated with acute tubular necrosis.
    4. Gentamicin is associated with ototoxicity.
    5. Neuromuscular blockade is associated with the use of neomycin.
    1. Penicillins
    2. Cephalosporins
    3. Vancomycin
    4. Macrolides
    5. Tetracyclines

    Author of lecture Aminoglycosides – Bacterial Protein Synthesis Inhibitors (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD


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