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Acute Rheumatic Fever

by Peter Delves, PhD
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    00:01 Acute rheumatic fever is quite an interesting type of autoimmune disease.

    00:07 It occurs due to molecular mimicry between group A Streptococcus pyogenes and human antigens.

    00:16 The Streptococcus pyogenes M protein and N-acetyl-glucosamine have structures that are very similar to cardiac myosin, laminin and other self antigens.

    00:29 The result is a carditis caused by these cross-reactive antibodies that recognize valve endothelium and laminin.

    00:40 There is also cross reaction of Th1 cells and Th17 cells.

    00:48 And these release inflammatory cytokines.

    00:52 The inflammatory lesions can also affect the joints, the subcutaneous tissue and the CNS.


    About the Lecture

    The lecture Acute Rheumatic Fever by Peter Delves, PhD is from the course Hypersensitivity and Autoimmune Disease.


    Author of lecture Acute Rheumatic Fever

     Peter Delves, PhD

    Peter Delves, PhD


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