Acute Phase Response

by Peter Delves, PhD

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    Another important part of the initial response to infection and tissue damage is something called the acute phase response. And this is involved with enhancing host resistance to infection or damage, to minimizing tissue injury and to promoting the resolution and repair of the inflammatory lesion. As we’ll hear, inflammation, at least acute inflammation is simply the immune system doing its job. It’s a beneficial thing. However, there is often a degree of collateral damage, if you like, where some of our body tissues become damaged somewhat by the inflammatory response. And a major role for the so called acute phase response is to help promote the resolution and repair of the inflammatory lesion. So what exactly is the acute phase response? Well, it’s an immediate response following infection or tissue damage. And it involves a changing concentration of many, many different molecules. Most of them increase quite dramatically in response to infection or damage. A few of them actually decrease in concentration. But the majority, they increase in concentration. There are many different aspects to acute phase responses, but one of them is that cytokines released following activation through Pathogen Recognition Receptors as we’ve just heard. Some of those cytokines can act on the liver, to increase the production up to a thousand fold of the secretion of a variety of acute phase proteins. Just going to give you three examples here; these three cytokines, interleukin-1β, interleukin-6 and tumor necrosis factor α, can cause increased production of the acute phase proteins, C-reactive protein (CRP), complement component C3, and fibrinogen which is involved in blood clotting. So it’s just three examples of acute phase proteins. As I’ve already mentioned, there are many, many, many others. So, let’s look now at a little bit more detail at the inflammatory process. Originally,...

    About the Lecture

    The lecture Acute Phase Response by Peter Delves, PhD is from the course Innate Immune System. It contains the following chapters:

    • The Acute Phase Response
    • Cardinal Signs of Inflammation
    • Acute and Chronic Inflammation Comparison

    Included Quiz Questions

    1. Fibrinogen
    2. iNOS
    3. Lactoferrin
    4. IL-10
    5. IgG
    1. The development of inflammation
    2. The development of cancer
    3. The development of anemia
    4. The development of massive blood loss
    5. The development of changes in diet
    1. Cyanosis
    2. Heat
    3. Redness
    4. Swelling
    5. Pain
    1. Acute- physiological Chronic- pathological
    2. Acute- macrophage Chronic- neutrophil and T lymphocyte
    3. Acute- long term Chronic- short lived
    4. Acute- neutrophil Chronic- T lymphocyte and basophil
    5. Acute- severe Chronic- mild

    Author of lecture Acute Phase Response

     Peter Delves, PhD

    Peter Delves, PhD

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