Acute Inflammation

by Peter Delves, PhD

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides Innate Immune System.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    So let’s now turn to the normal inflammatory response to an infection, which would be acute inflammation. You only get chronic inflammation if things really go wrong. So, what happens usually following an infection? Well, in acute inflammation there are many different cell types that are involved and as we’ve already heard, neutrophils are really at the heart of the acute inflammatory response. If you were to ask me, well what is the most important cell in the acute inflammatory response? I’d probably say, it’s the neutrophil because, indeed it is. But neutrophils are normally present in the blood circulation. They need to get out of the blood circulation to the site where the infection is. So the blood vessel endothelium plays a very important role in acute inflammation. Mast cells in the tissues, and basophils in the blood are also important; as are eosinophils, which can be present both in the blood and in the tissues, platelets which are involved in clotting, and fibroblasts, which can also contribute to the acute inflammatory response. So many different cells involved, but also many different molecules. Proinflammatory cytokines like interleukin-1 and interleukin-18 that we’ve already mentioned. Chemokines - which are chemotactic cytokines that attract cells of the immune response to the site of the infection. The acute phase proteins that I’ve already mentioned, some of which are produced by the liver as you saw. Adhesion molecules, allowing cells of the immune response to adhere to the blood vessels and then get out to the site of the infection. Complement, which we’ll discuss in detail in a few moments. Histamine which is released from mast cells and basophils, as are prostaglandins and leukotrienes. Histamine, prostaglandins and leukotrienes are very good examples of inflammatory mediators, along with the already mentioned cytokines which can contribute...

    About the Lecture

    The lecture Acute Inflammation by Peter Delves, PhD is from the course Innate Immune System. It contains the following chapters:

    • Acute Inflammation
    • Acute Inflammation Consequences

    Included Quiz Questions

    1. C5a
    2. Prostaglandin
    3. Leukotriene
    4. Histamine
    5. IL-18
    1. Fibrinogen
    2. Histamine
    3. Leukotrienes
    4. Prostaglandins
    5. Cytokins
    1. C5a
    2. Histamine
    3. Bradykinin
    4. IL-18
    5. ICAM

    Author of lecture Acute Inflammation

     Peter Delves, PhD

    Peter Delves, PhD

    Customer reviews

    5,0 of 5 stars
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1  Star