Let's turn the tables now and go to the last two diseases.
Again, they get short thrift only because they're not common in most parts of the world
and they're not as common today as they were certainly in the 1200-1300s.
The first of those is Yaws, and this is caused by Treponema pallidum pertenue.
It is a granulomas disease and typically one will see lesions
as you see in the picture here on the surface of the skin which are papilloma
like so you might think wart like but even larger.
With variable skin, some which may look like granulomas in the skin.
Typically you’ll have nodules under the skin as well.
This disease if unrecognized and untreated,
can go on to progress to destructive lesions underlying very much like the gummas
that we talked about for Treponema pallidum, syphilis.
So one can have bony lesions, lymph tissue, connective tissue, etc.
Yaws, is most directly transmissible via direct contact with the lesions
which works press a large number of active Treponema at their surface.
The treatment is penicillin just as it is with Treponema pallidum.
And then Pinta, the last of the three and this is caused by the Treponema carteneum
and this is typically seen as a small pruritic papules as you can see on the image on the slide
that those can progress both in a recurrent fashion or an ongoing fashion to cause raised,
scarring or keloid formation in some and certainly later onset with depigmentation.
So one might see a patient walking around a country from Africa,
for example, where one can still see Pinta, and see multiple pinpoint areas of hypopigmentation.
That would be a patient who might suffered from Pinta.
Same transmission as with Yaws, same transmission as with syphilis -
direct contact with lesions, any lesion with any form of Treponema is teaming with pathogen,
so just say no, hands-off.
Treatment for Pinta is also with penicillin. Both Yaws and Pinta
have a much slower progression without the severe additional manifestations we talked about in syphilis.
This is a long session talking about Treponema,
I would like to say that these diseases are historic only but unfortunately,
syphilis cause by Treponema pallidum is alive and well today
and you’ll need to know all about it cuz I guarantee you’ll be seeing lots of patients with it.