Type 1 Diabetes and Alzheimer's Disease

by Georgina Cornwall, PhD

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    Another disorder that we now know has a genetic component has been fairly elusive for a long time, I’d say that most of my life is diabetes type 1. It has a pretty complex inheritance but definitely monozygotic concordance and dizygotic concordance that differs substantially from each other suggesting that there is indeed a genetic component. We have realized for a while that it’s an autoimmune disease and that someone who has type 1 diabetes, their beta cells become destroyed by their own immune system. But the question has been why would our own immune system do that. What’s gone wrong? It turns out that there is a genetic component. It seems to be associated with major histocompatibility complex genes on chromosome 6. Here’s going to be a pretty complex graphic. This one, I think you can understand. But this one, we have a lot of different things going on. We’re really just highlighting the small region of chromosome 6. Now there is a yellow region and a blue region in here. These are both HLA class I and HLA class II respectively. These are human leukocyte antigens. They present antigens to the lymphocytes. You can see clearly that there are a lot of genes in these two regions. By no means do you need to dig into the depths and understand what each of those are unless of course, you go on to specializing the genetics of type 1 diabetes mellitus. But clearly complex inheritance and we do know where some of the genes associated with it at least are located. Putting those pieces together, we now have one more disorder to cover. That disorder is going to be Alzheimer's. For again, a long time, we have known that this is a fairly frequent disease of the elderly. It...

    About the Lecture

    The lecture Type 1 Diabetes and Alzheimer's Disease by Georgina Cornwall, PhD is from the course Multifactorial Inheritance. It contains the following chapters:

    • Type 1 Diabetes
    • Alzheimer's Disease

    Author of lecture Type 1 Diabetes and Alzheimer's Disease

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD

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