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Lymphadenopathy: Thymus Disorders – White Blood Cell Pathology

by Carlo Raj, MD
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    The way to approach thymic pathology in this section would be, well, is the thymus present? So maybe perhaps thymic hypoplasia or is there too much thymus activity. Let’s take a look. First, we’ll take a look at a congenital disorder that you should be quite familiar with in which, literally, the thymus does not form. This obviously is going to bring you to a topic of DiGeorge. So DiGeorge syndrome as you see in the picture here is showing you that the third and fourth pharyngeal pouches, which are normally responsible for developing the superior and inferior parathyroids and then also the third pharyngeal pouch, not only does it give rise to your inferior parathyroid, but it will also give rise to your thymus. And the DiGeorge syndrome, as you know, chromosome 22, long arm 11, that you don’t have this. Abnormal development of third and fourth pharyngeal pouches, loss of the thymus, now how’s your patient presenting? Well, you know about recurrent infections. Recurrent infection has a long list of differentials including DiGeorge, including your Chédiak-Higashi, including chronic granulomatous disease, including Bruton's agammaglobulinaemia, Wiskott-Aldrich, the list goes on and on and on. And those become important in immunology. Here, if the thymus is not present, then your patient is most likely susceptible more so to viral infections, but you know the peculiar symptom that you’re going to find here that you would in other conditions, that have recurrent infection will be the fact that if for example, if you placed pressure or if you snapped on your facial nerve, that you would have Chvostek sign, or in other words, you're eliciting tetany or perhaps a cuff around the arm and therefore resulting in carpopedal spasms or oral mucosa type of numbness, right? All of these put together with...

    About the Lecture

    The lecture Lymphadenopathy: Thymus Disorders – White Blood Cell Pathology by Carlo Raj, MD is from the course Lymphadenopathy – White Blood Cell Pathology (WBC).


    Included Quiz Questions

    1. 22q11 deletion
    2. 15q11deletion
    3. 5p-deletion
    4. SMN1 deletion
    5. 15q13deletion
    1. … third and fourth pharyngeal pouches.
    2. …first and second pharyngeal pouches.
    3. …second and third pharyngeal pouches.
    4. …second and fourth pharyngeal pouches.
    5. …fourth and fifth pharyngeal pouches.
    1. Trousseau's sign
    2. Carnett's sign
    3. Babinski sign
    4. Aaron sign
    5. Chvostek sign

    Author of lecture Lymphadenopathy: Thymus Disorders – White Blood Cell Pathology

     Carlo Raj, MD

    Carlo Raj, MD


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