Testosterone Effects

by Thad Wilson, PhD

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    How do you transport testosterone in the blood? Because remember testosterone is a steroid hormone, meaning that it is lipophilic. Therefore you need to bind something to it to carry it around. Sex hormone-binding globulin binds about 44 or so percent of the testosterone. The rest of it is bound with two other items, either albumin or corticosteroid-binding globulin. Interesting here that a glucocorticoid such as cortisol can use the same binding globulin as testosterone. That leaves about 2% free and it's only the free testosterone that's going to have biological action. Testosterone has its biological action by binding to a nuclear receptor. Now what does it do in the peripheral tissue? Well part of it gets converted. So testosterone gets converted to DHT, which is more potent. It also is converted sometimes to 17-ketosteroids. So there is some peripheral conversion that could take place of the testosterone that's circulating around then the rest of it, however, binds to nuclear receptors to undergo protein transcription and translation. Whatever is circulating around though will eventually be metabolized by the kidney and exited out by the urine. These nuclear receptors for both testosterone and DHT bind to these androgen receptors and translocate into the nucleus so that this process involves making new proteins. Thus, testosterone responses and DHT responses will be a bit slower than some of the other hormones. It takes time to make a new protein to bind to DNA, go to transcription and translation. So what are these effects of testosterone? Well first, there is a large effect on both bone growth and connective tissue growth. Muscle growth is very important and part of testosterone's effect. There are also effects on the reproductive organs. Secondary sex characteristics will be engaged such as growth of the voice box or larynx...

    About the Lecture

    The lecture Testosterone Effects by Thad Wilson, PhD is from the course Reproductive Physiology.

    Included Quiz Questions

    1. Connective tissue
    2. Sweat glands
    3. Peripheral nerves
    4. Blood vessels

    Author of lecture Testosterone Effects

     Thad Wilson, PhD

    Thad Wilson, PhD

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