T-Cell Development – Lymphocyte Development

by Peter Delves, PhD

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    Unlike B-cells which directly develop in the bone marrow; remember B, bone marrow. T-cells develop in the thymus. They arise from hematopoietic stem cells in the bone marrow, like just virtually every other cell of the immune system. But they need to travel from the bone marrow to the thymus in order to become mature. And that’s where they recombine their T-cell receptor genes and so forth. So T-cell precursors enter the thymus, and then they develop into the different types of T-cell that exists. And these are predominantly of three different types: helper T-cells, cytotoxic T-cells which are often also referred to as cytotoxic T-lymphocytes or CTLs. They’re exactly the same thing, cytotoxic T-cell or cytotoxic T-lymphocyte. And naturally occurring regulatory T-cells or Tregs. Following their development in the thymus, these various types of T-cells move to the secondary lymphoid tissues - the lymph nodes, the spleen, the mucosa-associated lymphoid tissue. So the thymus is where T-cells develop. Let’s have a look at exactly what is going on in the thymus as regards T-cell development. We can see in this section of thymus that there are two clearly different areas that are stained differently. The darker area is the cortex and this is densely packed with developing T-cells. Whereas the lighter staining area is the medulla, and this contains more mature T-cells. Upon arriving in the thymus, the T-cells undergo a process that’s referred to as thymic education. You can think of the thymus as being like a school for T-cells. It’s where they learn to recognize our own variants of the MHC molecules and where any reactivity against self antigens is eliminated. They pass through the thymus, going through the cortex and the medulla. Initially in the cortex they interact with thymic epithelial cells, and then as they...

    About the Lecture

    The lecture T-Cell Development – Lymphocyte Development by Peter Delves, PhD is from the course Adaptive Immune System.

    Included Quiz Questions

    1. CD1
    2. CD2
    3. CD3
    4. CD4
    5. CD5
    1. T cell precursor
    2. Helper T cell
    3. Cytotoxic T cell
    4. CTL
    5. Treg
    1. CD3 epsilon/gamma and CD3 epsilon/delta
    2. CD3 alpha/beta and CD3 epsilon/gamma
    3. CD3 alpha/beta and CD3 epsilon/delta
    4. CD3 epsilon/gamma and CD3 gamma/delta
    5. CD3 gamma/alpha and CD3 delta/beta
    1. Interaction with T cell precursors stored in the thymus
    2. Interaction with thymic epithelial cells in the cortex
    3. Interaction with dendritic cells
    4. Interaction with macrophages
    5. Interaction with cells in both the cortex and medulla of the thymus

    Author of lecture T-Cell Development – Lymphocyte Development

     Peter Delves, PhD

    Peter Delves, PhD

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