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T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development

by Peter Delves, PhD
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    About the Lecture

    The lecture T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • T-Cell Development in the Thymus
    • Genetic Recombination of TCR Genes

    Included Quiz Questions

    1. CD4 and CD8
    2. An αβ and a γδ T-cell receptor
    3. A TCR and a BCR
    4. MHC class I and MHC class II
    5. CD3 and CD4
    1. Positive selection: T cells that can recognize self MHC are saved from apoptosis
    2. Positive selection: T cells that recognize self MHC undergo apoptosis
    3. Positive selection: assigning CD4 and CD8 molecules to T cells- making them double positive
    4. Negative selection: selecting out any T cells that are CD4 or CD8 negative
    5. Negative selection: T cells that recognize self MHC undergo apoptosis
    1. Mature T cells do not recognize autoantigen
    2. Mature T cells contain either CD4 or CD8
    3. Mature T cells recognize self MHC
    4. Mature T cells are double negative
    5. Mature T cells do not exhibit central tolerance

    Author of lecture T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development

     Peter Delves, PhD

    Peter Delves, PhD


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