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T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development

by Peter Delves, PhD
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    About the Lecture

    The lecture T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • T-Cell Development in the Thymus
    • Genetic Recombination of TCR Genes

    Included Quiz Questions

    1. CD4 and CD8
    2. An αβ and a γδ T-cell receptor
    3. A TCR and a BCR
    4. MHC class I and MHC class II
    5. CD3 and CD4
    1. ...positive selection: T cells that can recognize self MHC are saved from apoptosis.
    2. ...positive selection: T cells that recognize self MHC undergo apoptosis.
    3. ...positive selection: assigning CD4 and CD8 molecules to T cells- making them double positive.
    4. ...negative selection: selecting out any T cells that are CD4 or CD8 negative.
    5. ...negative selection: T cells that recognize self MHC undergo apoptosis.
    1. ...mature T cells do not recognize autoantigen.
    2. ...mature T cells contain either CD4 or CD8.
    3. ...mature T cells recognize self MHC.
    4. ...mature T cells are double negative.
    5. ...mature T cells do not exhibit central tolerance.

    Author of lecture T-Cell Development in Thymus and Genetic Recombination of TCR – Lymphocyte Development

     Peter Delves, PhD

    Peter Delves, PhD


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