Sympathomimetic Activators

by Pravin Shukle, MD

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    Hi, welcome to pharmacology by Lecturio. We are going to continue our journey talking about the autonomic nervous system and the drugs that we use to control it. My name is Dr.Pravin Shukle. We are going to talk today about some of the drugs that are mimicking the sympathetic nervous system. Let's take a look at sympathomimetics. We have direct activators and indirect activators that imitate the effects of excess adrenaline on the human body. Let's first talk about alpha agonist. Now the classical drug of alpha agonist category is norepinephrine. It is a non selective agent. Alpha 1 selective agent is phenylephrine and an alpha 2 selective agent is clonidine. It is important that you memorise these drugs. They are going to be on your exam and they are going to be prototypical drugs. We won't talk about other alpha 1 and alpha 2 selective drugs, we will just focus on these ones. What about beta agonist. The classical or prototypical beta agonist is epinephrine which is endogeneously produced amine. The nonselective agents are epinephrine and isoproterenol. The beta 1 selective agonist is dobutamine. And the beta 2 selective agonist is albuterol and salbutamol. Salbutamol is more commonly known as ventolin. And these are inhaled drugs. Remember that beta 2 means you have two lungs. These are drugs that are active in the lungs, they are generally inhaled medications. In terms of the indirect activators, there is release of adrenaline from the terminal nerve button and that's caused by amphetamines. And there are reuptake inhibitors, drugs like cocaine and tricyclic antidepressants work through that mechanism. The indirect activators also include dopamine. Now dopamine at low dose activates dopamine receptors. At intermediate dose, activates beta receptors, and at very high doses, activates alpha receptors. I'm going to tell you a...

    About the Lecture

    The lecture Sympathomimetic Activators by Pravin Shukle, MD is from the course ANS - Pharmacology.

    Included Quiz Questions

    1. High dose
    2. Low dose
    3. Dopamine never activates alpha-adrenergic receptors
    4. Dopamine always activates alpha-adrenergic receptors
    5. Intermediate dose
    1. Phenylephrine
    2. Epinephrine
    3. Intermediate dose dopamine
    4. Dobutamine
    5. Isoproterenol
    1. By blocking the transport molecule hindering reuptake of norepinephrine and dopamine.
    2. By directly binding to alpha-adrenergic receptors
    3. By increasing the conversion of tyrosine to norepinephrine and dopamine.
    4. By augmenting release of norepinephrine from the terminal button.
    5. By directly binding to beta-adrenergic receptors

    Author of lecture Sympathomimetic Activators

     Pravin Shukle, MD

    Pravin Shukle, MD

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