Summary: Pituitary Hormone Excess

by Michael Lazarus, MD

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    00:01 Let's summarize what we learned from the previous four cases and compare and contrast the different conditions causing hormone excess from the anterior pituitary.

    00:11 First of all, ACTH.

    00:13 The clinical syndrome consists of moon faces, centripetal obesity, the presence of striae, diabetes, and hypertension.

    00:21 This is Cushing disease most likely caused by ACTH-secreting pituitary adenoma.

    00:27 The best tests to order here are a 24-hour urine cortisol, a dexamethasone suppression test, a midnight salivary cortisol level, and a serum ACTH level.

    00:40 For TSH, these patients present with goiters and hyperthyroidism, and under these circumstances, a TSH-secreting pituitary adenoma should be ruled out.

    00:50 Under these circumstances, the TSH is usually normal or elevated, and an increased T4 can be found as well.

    00:58 Excess growth hormone release from the anterior pituitary presents with acromegaly.

    01:03 This manifests as increased spacing between the teeth of the lower jaw, enlarged hands, feet, head, and tongue.

    01:12 Here, the best test to order is IGF-1 level, check to screen, and then an oral glucose tolerance test is used to confirm the diagnosis.

    01:22 Prolactin will produce galactorrhea and amenhorrhea.

    01:26 The clinical condition is usually a prolactinoma, and here, the best test to order is a serum prolactin level.

    About the Lecture

    The lecture Summary: Pituitary Hormone Excess by Michael Lazarus, MD is from the course Pituitary and Hypothalamic Disorders.

    Included Quiz Questions

    1. Goiter and hyperthyroidism
    2. Goiter and hypothyroidism
    3. Goiter and hyperparathyroidism
    4. Hyperparathyroidism and hyperthyroidism
    5. Hypoparathyroidism and hypothyroidism

    Author of lecture Summary: Pituitary Hormone Excess

     Michael Lazarus, MD

    Michael Lazarus, MD

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