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Testis, Spermatogenesis and Sperm Maturation: Sertoli Cell Secretions

by Thad Wilson, PhD
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    So what is the various testosterone doing and how does this affect spermatogenesis? We need to delve in a little bit deeper to the testis. Here in the testis, these Sertoli cells are going to be the primary spot in where spermatogenesis occurs. Leydig cells, remember, are located outside of where the Sertoli cells are. The Sertoli cells are where sperms start to develop. The testes are located outside of the body. They're located outside of the body because the temperature is cooler. It needs to maintain a slightly lower temperature than body temperature for spermatogenesis to occur. Therefore, these Sertoli cells are located right where they are for that particular reason. Sertoli cells need to be in close proximity to Leydig cells. Why? Because they need the testosterone that Leydig cells are producing because without that testosterone they're not going to undergo spermatogenesis and have the growth factor and regulatory peptides cannot work in the same way. Where do these growth factors and regulatory peptides come from? Sertoli cells. So really it's a combined effort for spermatogenesis to occur as well as for them to develop properly. So let's talk through that process in a little bit more detail. You need testosterone, androgen-binding protein. These testosterone levels need to be maintained at high levels and you need these growth factors for the spermatogenesis maturation process to occur. Spermatogenesis. Spermatogenesis is going to occur in the Sertoli cells. There is going to be a start of this process where you start to form a spermatid forming a primary then a secondary and eventually will fully develop into having both a head region and a tail but they're not quite fully developed yet. They need to have a fully developed head, a neck with a number of different mitochondria in it...

    About the Lecture

    The lecture Testis, Spermatogenesis and Sperm Maturation: Sertoli Cell Secretions by Thad Wilson, PhD is from the course Reproductive Physiology.


    Author of lecture Testis, Spermatogenesis and Sperm Maturation: Sertoli Cell Secretions

     Thad Wilson, PhD

    Thad Wilson, PhD


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