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Secondary Lymphoid Tissues – Lymphocyte Activation

by Peter Delves, PhD
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    The secondary lymphoid tissues have structures that support the activation of the adaptive immune response. There are a whole variety of cells within the secondary lymphoid tissues. Different types of T-cells, B-cells, the antibody secreting plasma cells, dendritic cells which show antigen to T-cells, follicular dendritic cells which show antigen to B-cells, macrophages and natural killer cells; all of these cell types are present. So really it’s the secondary lymphoid tissues where the adaptive response becomes activated. So let’s look at these different types of secondary lymphoid tissue. Lymph nodes are scattered throughout the body. Lymphocytes can circulate around the body in the blood circulation and in the lymphatic circulation. And these two different circulations are not isolated from each other, there are connections between them. Particularly important being the thoracic duct which permits lymphocytes that are circulating around the lymphatic system to re-enter the blood circulation. Lymph nodes throughout the body are connected with one another via the lymphatic circulation, and they also all have a blood supply. So antigen can enter the lymph node either through the lymphatic vessels or potentially through the blood vessels. And likewise, lymphocytes and other cells of the immune response can enter the lymph node either via the lymphatics or via the blood circulation. The outside of the lymph node is surrounded by a collagenous capsule. Trabeculae penetrate into the inside of the lymph node from this capsule. Underlying the capsule is the subcapsular sinus. The inner part of the lymph node is referred to as the medulla. And there is a sinus where cells from the medulla and fluid from the medulla can drain into, and this is the medullary sinus. Antigen, particularly antigen being carried by dendritic cells, can arrive in the lymph node via the afferent lymphatic vessel. Lymphocytes can...

    About the Lecture

    The lecture Secondary Lymphoid Tissues – Lymphocyte Activation by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • The Secondary Lymphoid Tissues
    • A Closer Look on the Lymph Nodes
    • A Closer Look on the Spleen
    • Mucosa-Associated Lymphoid Tissue

    Included Quiz Questions

    1. Cortex
    2. Paracortex
    3. Medulla
    4. Medullary sinus
    5. Capsule
    1. Secondary lymphoid tissues
    2. Bloodstream
    3. Thymus
    4. Bone Marrow
    5. Mucosal surfaces
    1. Afferent lymphatic vessel
    2. High endothelial venule
    3. Efferent lymphatic vessel
    4. Lymph node artery
    5. Medullary sinus
    1. Central arteriole- periarteriolar lymphoid sheath (T cells), Follicular arterioles- follicles (B cells)
    2. Central arteriole- periarteriolar lymphoid sheath (B cells), Follicular arterioles- follicles (T cells)
    3. Central arteriole- follicles (B cells), Follicular arterioles- periarteriolar lymphoid sheath (T cells)
    4. Trabecular artery- follicles (B cells), Central arteriole- periarteriolar lymphoid sheath (T cells)
    5. Trabecular artery- periarteriolar lymphoid sheath (B cells), Central arteriole- follicles (T cells)

    Author of lecture Secondary Lymphoid Tissues – Lymphocyte Activation

     Peter Delves, PhD

    Peter Delves, PhD


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