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Anti-Herpes Agents: RNA Polymerase Inhibitors and Other Drugs – Antiviral Drugs

by Pravin Shukle, MD
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    Let's move on to RNA polymerase agents and other agents. Once again we're talking about nucleic acid synthesis. But now we're talking about RNA as oppose to DNA. Foscarnet that is probably the best known in this drug. It does not require phosphorylation for activity. It is not an antimetabolite. Now it inhibits both DNA and RNA polymerase. And it also inhibits HIV reverse transcriptase. So it's kind of a convenient drug to use for multiple situations. It inhibits DNA polymerase in acyclovir resistant strains that are also thymidine kinase deficient. So it's quite a useful drug in that regard. Adverse events are quite severe. So nephrotoxicity, up to one-third of patients can develop nephrotoxicity with this agent. So we tend to be very careful in monitoring renal function in people who are on this drug. Gastro, sorry, genitourinary ulceration can also occur in patients who are on foscarnet as well. So we keep an eye out for that too. In terms of neurological side effects patients often complain of headache. I see that all the time in patients that I co-manage with our HIV specialist who are hepatitis specialists. We also see hallucination and seizures with this agent on rare occasion. Let's move on to the other drugs. These are drugs that don't really fit in other categories. Vidarabine is an adenine analog. It has very good activity against systemic infections, HSV,VZV and cytomegalovirus. It doesn't have any significant effect on genital lesions. It's more about a systemic infection treatment. The next agent that I want to talk about is fomivirsen. So this is an interesting drug. It's an anti-sense oligonucleotide. So to give you an idea of the size of this molecule, take a look at vidarabine in top right hand corner and then take a look at...

    About the Lecture

    The lecture Anti-Herpes Agents: RNA Polymerase Inhibitors and Other Drugs – Antiviral Drugs by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Included Quiz Questions

    1. Foscarnet
    2. Vidarabine
    3. Pencyclovir
    4. Ganciclovir
    5. Fomivirsen
    1. Fomivirsen
    2. Vidarabine
    3. Ganciclovir
    4. Acyclovir
    5. Foscarnet

    Author of lecture Anti-Herpes Agents: RNA Polymerase Inhibitors and Other Drugs – Antiviral Drugs

     Pravin Shukle, MD

    Pravin Shukle, MD


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