Relapsing Fever – Borrelia

by Sean Elliott, MD

My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      01-24 Borrelia.pdf
    • PDF
      Download Lecture Overview
    Report mistake

    00:01 So, having talked at length about Lyme disease which is what we most often experience as a Borrelia disease worldwide, there are other forms of Borrelia that we do need to be aware of, typically associated with Borrelia recurrentis or a related species in the Borrelia family.

    00:19 These entities are known as Relapsing fevers or sometimes tick associated or vector associated relapsing fever.

    00:28 Borrelia recurrentis, as you see there, is associated with a lice or louse borne epidemic relapsing fever and patient’s typical have a single relapse and then they’ll be done.

    00:40 Other tick borne relapsing fevers, however, may have multiple relapses which keep going on and going on.

    00:48 The febrile phase of the relapsing fever is typically in abrupt onset, very high fevers. Temperature is associated with shaking chills, the rigors and the muscle aches.

    01:01 So again, you may be thinking that just sounds like the really bad flu I had last winter.

    01:05 Well, yes, you're right. So the febrile phase almost is like very severe flu like illness and it lasts similar to the flu from three to seven days.

    01:15 Then the patient's free the sigh of relief.

    01:18 They have entered the afebrile, the clinically healthy stage and this lasts for about a week and then unfortunately the same thing happens again - the febrile symptoms return just as bad as they were before.

    01:30 In the Borrelia recurrentis it's typically a single relapse and the tick associated illness its ongoing relapses as the Borrelia organism undergoes small antigenic changes in its outer structure each time of which triggers a separate and new immune reaction.

    01:51 So you're basically blessed or cursed with ongoing trigger of the immune system because of this.

    01:57 Finally, diagnosis.

    02:01 I mentioned before that one can do dark field microscopy but it’s very difficult to find the organism even in biopsy of a primary lesion for Lyme disease and in the recurring fevers there's nothing specific to biopsy.

    02:14 So one can actually perform for Borrelia burgdorferi to diagnose Lyme disease and enzyme immunoassay looking for both immunoglobulin M and immunoglobulin G, EI antibodies and confirm those with Western blot analysis.

    02:32 In this schematic, you can see on the far right of the schematic the typical bands, what you're seeing is positive for an IgG, immunoglobulin G, to Borrelia burgdorferi and then compare the different lanes of the patient one through seven and match up how many the bands occur in correlation with the known bands, the known positive bands for Borrelia burgdorferi.

    02:59 And there are standards established in the states for the Centers for Disease Control and the other parts of the world as well in which one has two or more positive IgM bands and three or more positives specific IgG bands and that constitutes a positive diagnosis so very important to make the accurate and proper diagnosis so that the treatment can be appropriately administered.

    03:22 For the recurring fevers, however, it’s easier to do a Wright stain or a Giemsa stain of a blood smear, and look for presence of the organisms within the erythrocytes.

    03:34 As you can see, if you focus closely on this image, within the erythrocytes, there are several darker purple dots which represent infection of those specific cells.

    03:44 Serologic tests as noted by the slide are useless, again, because the Borrelia undergoes antigenic variation so one would never be able to make a single antibody to cover all the different potential types of variating antigen discovery.

    04:00 So, that is what we know about Borrelia burgdorferi as the cause of Lyme disease recurrentis and other types of Borrelia causing recurring fevers all these are vector associated, all these are unfortunate things that you have to come across in the woods when all you simply want is a peaceful walk through the woods with your dog.

    About the Lecture

    The lecture Relapsing Fever – Borrelia by Sean Elliott, MD is from the course Bacteria.

    Included Quiz Questions

    1. Borrelia recurrentis
    2. Borrelia afzelii
    3. Borrelia hermsii
    4. Borrelia burgdorferi
    5. Borrelia mayonii
    1. 1 week
    2. 2 weeks
    3. 1 day
    4. 2 days
    5. 1 month

    Author of lecture Relapsing Fever – Borrelia

     Sean Elliott, MD

    Sean Elliott, MD

    Customer reviews

    5,0 of 5 stars
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1  Star