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Regulatory T-Cells, Cytotoxic T-Cells, Macrophages and Intraepithelial Lymphocytes – Cell-Mediated Immunity

by Peter Delves, PhD
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    About the Lecture

    The lecture Regulatory T-Cells, Cytotoxic T-Cells, Macrophages and Intraepithelial Lymphocytes – Cell-Mediated Immunity by Peter Delves, PhD is from the course Humoral Immunity and Cell-Mediated Immunity. It contains the following chapters:

    • Regulatory T-Cells
    • Cytotoxic T-Cells
    • Removal of Killed Cells by Macrophages
    • Intraepithelial Lymphocytes

    Included Quiz Questions

    1. CD8αα
    2. CD8αβ
    3. CD8ββ
    4. CD4αα
    5. CD4αβ
    1. Dendritic cells
    2. Mast cells
    3. Eosinophils
    4. Basophils
    5. Helper T cells
    1. Cytotoxic T cell mediated apoptosis is dependent on Fas and FasL interaction
    2. Cytotoxic T cells would downregulate the production of FasL and upregulate the release of Granzymes
    3. Cytotoxic T cells would increase the amount of Granzymes released into order to create a concentration gradient that will bring them into the tumor cell
    4. Caspase activation would increase
    5. Cell death could only be mediated by phagocytosis- apoptosis would be impossible
    1. A healthy cell has internal phosphatidylserine, external phosphatidylserine signals to macrophages to phagocytose the cell
    2. Internal phosphatidylserine makes a cell more likely to be phagocytosed by macorphages
    3. External phosphatidylserine signal to Dendritic cells that an antigenic cell has been engulfed
    4. Treg cells recognize external phosphatidylserine and down regulate release to cytokines, which leads to an enhanced immune response
    5. Macrophages will not engulf a cell with external phosphatidylserine

    Author of lecture Regulatory T-Cells, Cytotoxic T-Cells, Macrophages and Intraepithelial Lymphocytes – Cell-Mediated Immunity

     Peter Delves, PhD

    Peter Delves, PhD


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