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Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation

by Peter Delves, PhD

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    00:01 It’s not only protein antigens of course that are recognized by the immune response.

    00:05 Most types of molecules can be recognized.

    00:08 So let’s look very briefly at what happens with lipid antigens.

    00:13 Well again, they can be processed and presented.

    00:17 The details are a little bit different but the overall concept is very similar.

    00:22 So for example here we have a glycolipid or lipoprotein antigen, and this can be endocytosed or phagocytosed just like protein antigens or indeed whole intact microorganisms can be taken up by the cell.

    00:38 So here we have the glycolipid or lipoprotein antigen, and this can be chewed up by lipases, rather than proteases chewing up proteins.

    00:49 Lipases can chew up these particular types of antigen.

    00:53 Meanwhile in the endoplasmic reticulum, the CD1 molecule is being produced.

    00:58 Now this is a molecule that is very, very similar to MHC Class I.

    01:02 It’s not an MHC Class I molecule, but it has a very similar structure.

    01:06 It’s not identical structure, but a very similar structure.

    01:08 And it can bind lipid antigens.

    01:14 So again it needs to be exported, it needs to get together with the processed lipid antigen.

    01:20 So it needs to be exported from the endoplasmic reticulum.

    01:23 And then these two vesicles need to get together just as we saw previously with protein antigen and MHC Class II.

    01:30 And the lipid antigens can be inserted into the binding groove of the CD1 molecule which is specialized to bind to lipid antigens, and then this will be taken to the cell surface where this combination of lipid plus CD1 can be presented to αβ T-cells, to γδ T-cells or indeed to NKT-cells.


    About the Lecture

    The lecture Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System.


    Author of lecture Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


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    Very well explained.
    By Alejandra L. on 19. February 2021 for Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation

    The material was very well presented and easy to understand. I love that the videos are short an easy to digest. I would recommend this lecture to any of my friends.

     
    Great Lecture series!
    By Arjavon T. on 13. October 2020 for Presentation of Lipid Antigens by CD1 – Antigen Processing and Presentation

    I have found all of Dr. Delves' lectures to be very insightful yet quite concise. Thank you for your hard work.