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Preparation of Amines

by Adam Le Gresley, PhD
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    The lecture Preparation of Amines by Adam Le Gresley, PhD is from the course Medical Chemistry.


    Included Quiz Questions

    1. Amines, being very electrophilic, are not able to displace halide ions from a haloalkane.
    2. The reactivity order of haloalkanes with ammonia is 1° haloalkanes > 2° haloalkanes > 3° haloalkanes.
    3. The haloalkanes and ammonia undergo SN2 type nucleophilic substitutions.
    4. The reaction between NH3 or an amine can give rise to a mixture of amines.
    5. The nucleophilicity order of N-atom in amines is 3° amine > 2° amine > 1° amine > NH3.
    1. Due to less availability of the lone pair of nitrogen as it gets partially delocalized with the pi electrons of the benzene ring.
    2. Due to more availability of the lone pair of nitrogen due to electron donating effect of the benzene ring.
    3. Due to more electronegative nature of nitrogen atom, it does not take part in nucleophilic substitution.
    4. Due to more electron pulling effect of hydrocarbon chain associated with the halogen atom, it prevents the participation of halogen in nucleophilic substitution.
    5. Due to more electronegative nature of the halogen atom, it does not participate in nucleophilic substitution.
    1. The difference between the electronegativities of hydrogen and nitrogen atoms and the presence of an unshared pair of electrons on the nitrogen atom
    2. High electronegativity of hydrogen atom and presence of a lone pair of electrons on the nitrogen atom
    3. Low electronegativity of nitrogen atom and presence of a lone pair of electrons on the nitrogen atom
    4. The electron pulling nature of hydrogen atom
    5. The electron pulling nature of alkyl or aryl groups attached to nitrogen atom
    1. Tetramethylammonium bromide (a quaternary ammonium salt)
    2. Dimethylamine and Bromoethane
    3. Ammonia and Bromobutane
    4. Methylamine and Bromopropane
    5. Ammonia, Hydrobromic acid, and But-2-ene
    1. The ionic nature of ammonium salt enables it to form hydrogen bonds with water molecules.
    2. The ionic nature of free amine prevents it from forming hydrogen bonds with water molecules.
    3. The free amines lack the unshared pairs of electrons on their hydrogen atoms to form hydrogen bonds with water molecules.
    4. The free amines form strong intramolecular hydrogen bonds which can not be broken by interactions with water molecules.
    5. The free amines lack the unshared pairs of electrons on their carbon atoms to form hydrogen bonds with water molecules.

    Author of lecture Preparation of Amines

     Adam Le Gresley, PhD

    Adam Le Gresley, PhD


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