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Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics)

by Pravin Shukle, MD
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    The lecture Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.


    Included Quiz Questions

    1. Transpeptidation to form crosslinking.
    2. Glycosylation to form polymers.
    3. Hydrolysis to form monomers.
    4. Nucleophilic attack to form polymers.
    5. Production of free radicals.
    1. The beta-lactam ring of penicillin binds to the transpeptidase used for crosslinking and inhibits it.
    2. The active carboxyl group of penicillin binds to proteins of the electron transport chain and inhibits them.
    3. The carbonyl carbon of penicillin forms a bond with cell wall polymerase and inhibits it.
    4. Penicillin is an enzyme that ubiquitinates all bacterial enzymes to breakdown bacterial cell walls.
    5. Penicillin activates the body's immune function to attack bacteria cells.
    1. B-lactamases break down penicillin and neutralize it.
    2. Elevated internal pH neutralizes penicillin.
    3. Elevated osmotic pressure neutralizes penicillin.
    4. Bacteria have developed enzymes that glycosylate penicillin to neutralize it.
    5. Bacteria have developed cell wall materials with extreme positive charges to repel penicillin.

    Author of lecture Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD


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