Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics)

by Pravin Shukle, MD

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    About the Lecture

    The lecture Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology.

    Included Quiz Questions

    1. Piperacillin
    2. Ampicillin
    3. Amoxicillin
    4. Methicillin
    5. Nafcillin
    1. Transpeptidation to form crosslinking.
    2. Glycosylation to form polymers.
    3. Hydrolysis to form monomers.
    4. Nucleophilic attack to form polymers.
    5. Production of free radicals.
    1. Ticarcillin is contraindicated with administration of aminoglycosides.
    2. Methicillin is associated with interstital nephritis.
    3. Nafcillin is associated with neutropenia.
    4. Ampicillin is a wide spectrum antibiotic that is susceptible to beta lactamases.
    5. Oxacillin is a narrow spectrum penicillin.
    1. Structural changes in penicillin binding protein rendering immunity to penicillins.
    2. Elevated internal pH neutralizes penicillin.
    3. Beta lactamases break down the beta lactam ring of penicillins rendering them inactive.
    4. Bacteria have developed enzymes that glycosylate penicillin to neutralize it.
    5. Bacteria have developed cell wall materials with extreme positive charges to repel penicillin.

    Author of lecture Penicillins – Cell Wall Synthesis Inhibitors (Antibiotics)

     Pravin Shukle, MD

    Pravin Shukle, MD

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