Lectures

Pathway Regulation

by Kevin Ahern, PhD
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    00:00 Now to summarize all this together we have the glucagon epinephrine pathway compared to the insulin pathway.

    00:06 And you can see that glucagon epinephrine is favoring the production of glucose through gluconeogenesis, through glycogen breakdown and also the production of energy through fat breakdown.

    00:18 It's inhibiting the use of glucose which is glycolysis and glycogen synthesis, and it's inhibiting the storage a fat.

    00:27 Insulin is favoring the opposite things. Insulin is favoring the use of glucose in glycolysis and glycogen synthesis, and it's favoring the synthesis of fat.

    00:37 On the other hand, it is inhibiting gluconeogenesis and glycogen breakdown and it's inhibiting fat breakdown as well.

    00:43 Now the pathway for glucagon and epinephrine is activated by protein kinase A and the kinase cascade, as we have seen numerous times.

    00:51 The insulin pathway is being activated by phosphoprotein phosphatase and the dephosphorylating enzymes that we have seen.

    00:59 Now we have gone through a fairly detail description here of the regulatory pathways involved in controlling many metabolic processes in the cell.

    01:09 But I hope what you have taken away in this scheme is that there is in fact a great coordination of these events such as the cell is operating as efficiently as it can just like that well oiled machine.


    About the Lecture

    The lecture Pathway Regulation by Kevin Ahern, PhD is from the course Metabolic Control.


    Included Quiz Questions

    1. ...it favors fatty acid synthesis.
    2. ...it stimulates FBPase2 to be active.
    3. ...it activates gluconeogenesis.
    4. ...it inhibits glycogen synthase.

    Author of lecture Pathway Regulation

     Kevin Ahern, PhD

    Kevin Ahern, PhD


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