Outcomes of Injury

by Richard Mitchell, MD, PhD

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    00:01 Okay, so we've been a long way.

    00:04 You and I, through this world of acute chronic inflammation, wound healing, etc.

    00:12 Let's review it very quickly on one slide.

    00:14 So you have injury.

    00:15 You have the initial vascular and cellular responses that give a rise to acute inflammation with our neutrophils.

    00:21 And in most cases, we go directly into chronic inflammation.

    00:27 Sometimes the acute inflammation is so severe that we get an abscess formation we get purulent, we get a big puss ball.

    00:34 It's still going to heal only by chronic inflammation.

    00:39 There are some forms of injury: recurrent persistent injury, viral infections and autoimmune disease that go directly to chronic inflammation.

    00:47 Okay.

    00:49 Ideally, as we go into chronic inflammation from all these various pathways, we get complete restoration of normal structure and function.

    00:59 Total regeneration, that is perfect, but it doesn't usually totally happen that way.

    01:05 And we have some combination, almost always of regeneration and scarring.

    01:11 And the scarring depends on the type of the tissue, whether it can regenerate or not.

    01:16 And how well the matrix is preserved? And with that, you've come full cycle and you are now an expert on acute and chronic inflammation in wound healing.

    About the Lecture

    The lecture Outcomes of Injury by Richard Mitchell, MD, PhD is from the course Acute and Chronic Inflammation.

    Included Quiz Questions

    1. Autoimmune diseases
    2. Abscesses
    3. Infarctions
    4. Burns
    5. Toxins

    Author of lecture Outcomes of Injury

     Richard Mitchell, MD, PhD

    Richard Mitchell, MD, PhD

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