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Other Levels of Prokaryotic Gene Regulation

by Georgina Cornwall, PhD
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    00:00 That has been looking at all of the mechanisms of possibility for control and transcription that we're aware of and in prokaryotic cells, of course, there are probably many more things that come into play. That covers here. We have other levels we could modulate transcription from. Keep in mind that ribosomes jump right onto that messenger RNA as it is being transcribed and the more ribosomes that are produced by other genes elsewhere, the more ribosomes jump on the strand and transcribe that DNA and we have that little Christmas tree looking thing and we have a high rate of production of proteins.

    00:45 All sorts of regulatory mechanisms come into play and putting together the subunits of the ribosome and all of the tRNAs and so on and so forth that are necessary to have successful translation of the messenger RNA. Finally, we could alter the protein structure.

    01:03 We have the protein produced and it is in an active form and it needs to be activated or inactivated according to whether that protein is necessary. Three levels of potential regulation for prokaryotic cells, of course, eukaryotes, we have many more levels of possible regulation and we will explore that in the next lecture at least what we know about it.

    01:30 Now at this point, you should be able to recognize the most common DNA binding motifs as well as explain how the inducible operon functions and explain how the repressible operon functions.

    01:45 Thank you so much for your attention. I will look forward to seeing you in our discussion of eukaryotic gene regulation.


    About the Lecture

    The lecture Other Levels of Prokaryotic Gene Regulation by Georgina Cornwall, PhD is from the course Gene Regulation.


    Included Quiz Questions

    1. A repressible gene is turned on because a repressor molecule is absent. By comparison, a gene that is induced is turned on because an inducer molecule is present.
    2. Repressible genes are turned on because an inducer molecule is present. By comparison, a gene that is induced is turned on because a repressor molecule is absent.
    3. A repressible gene is turned off and an induced gene is activated to be expressed.
    4. There is no functional difference between a gene that is derepressed and one that is induced.
    1. …transciptional, translational and post-translational levels.
    2. …DNA replication and DNA repair levels.
    3. …post-translational levels only.
    4. …translational levels only.
    5. …transcriptional levels only.

    Author of lecture Other Levels of Prokaryotic Gene Regulation

     Georgina Cornwall, PhD

    Georgina Cornwall, PhD


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