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Non-hemolytic Anemias

by Carlo Raj, MD
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    00:00 Under normocytic and non-hemolytic, once again, decreased reticulocyte count.

    00:05 Quickly walkthrough the pathogenesis, no initial change.

    00:09 So therefore, you give isotonic saline.

    00:12 Oh my goodness, isotonic saline is not RBCs.

    00:15 So if the patients come in and they have had hemorrhage, right? That’s blood loss.

    00:20 There is going to be decreased blood pressure.

    00:22 You have to give isotonic saline.

    00:24 Saline is NaCl.

    00:26 What are you going to do? You will now unveil the anemia in your patient, but they will appear as being normocytic non-hemolytic.

    00:35 Early stage iron disease, iron study is abnormal at first.

    00:39 That’s the first thing.

    00:40 The studies will be abnormal.

    00:42 But in terms of early type of peripheral blood smear, it will be normocytic, early.

    00:47 So the first thing that you’re looking for is, tell me once again, serum iron decreased, ferritin decreased, TIBC increased, transferrin saturation percentage decreased.

    00:58 Remember those four that we walked through in great detail.

    01:02 Now, the anemia of chronic disease, we talked about how the bone marrow might be compromised, normocytic and often remains normocytic.

    01:09 When we saw this early at microcytic, aplastic.

    01:13 Pancytopenia.

    01:14 So you can’t produce much of your myeloid lineage.

    01:18 Renal disease.

    01:18 Decreased EPO.

    01:19 Malignancy may result normocytic non-hemolytic anemia.

    01:25 Remember malignancy could be an underlying issue, chronically for anemia of chronic disease, ACD.

    01:29 I gave you breast cancer metastasizing into your bone marrow and that we called myelophthisic, normocytic non-hemolytic is my point and then bleeding.

    01:40 Bleeding might be taken place into different structures and therefore may result in anemia as well.

    01:45 Malignancy is a big one.


    About the Lecture

    The lecture Non-hemolytic Anemias by Carlo Raj, MD is from the course Normocytic Anemia – Red Blood Cell Pathology (RBC).


    Included Quiz Questions

    1. Isotonic saline
    2. Whole blood
    3. Fresh frozen plasma
    4. Cryoprecipitates
    5. Packed RBCs

    Author of lecture Non-hemolytic Anemias

     Carlo Raj, MD

    Carlo Raj, MD


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