00:01
So in summary,
when we think about
junctional problems,
we're going to know
of certain conditions.
00:06
Myasthenia Gravis,
Botulism,
Lambert-Eaton
myasthenic syndrome
are the three most important
junctional disorders to understand.
00:14
And we're going to review
each of those
in a subsequent lecture.
00:17
We're going to think of important
electrolytes or drugs,
heritable,
myasthenic syndrome,
and some antibiotics
that can also affect this area.
00:26
When we're evaluating patients,
and worrying about those diagnoses,
we want to focus on three things:
What is the distribution,
sensory findings, and reflex exam
for this patient?
Neuromuscular junction disorders
present with weakness.
00:39
And the weakness can be
anywhere in the body,
but should include
bulbar fibers.
00:43
We should see ptosis, diplopia,
dysarthria, and dysphagia.
00:47
The sensory findings
are normal.
00:49
The reflex exam is also normal
to maybe decreased.
00:52
And we're looking for that
important wildcard.
00:54
Presence of
fatigable weakness.
00:56
If it's not there,
that doesn't mean it's not
a neuromuscular
junction condition.
01:00
But if we hear fatigability,
this should tip us off
that this problem
may be from the junction.
01:06
And we're going to learn
how to use other tests
to evaluate patients
that are presenting
with this type of problem.
01:12
We're going to learn about
electrophysiology,
both the
nerve conduction study,
and EMG
are important test
to figure out
where this problem is.
01:19
To exclude
muscle and nerve problems,
and focus on the
neuromuscular junction
with repetitive stimulation.
01:26
We're going to learn about
important tests,
laboratory studies
that can also help
to evaluate these patients
including the
acetylcholine receptor antibody,
MuSK antibody,
and Voltage-Gated
Calcium Channel antibodies
that you see here.