00:00
And finally, let’s end up this interesting
and intriguing discussion with Malassezia.
00:07
It's not pizza, it's a superficial infection.
Most adults have colonization of the stratum
corneum, the outer layers of the skin, with
Malassezia, which is a yeast. It is a single
cell growing organism, sort of like Saccharomyces
cerevisiae, however Malassezia does not give
you beer or bread, it just gives you troubles.
Here on the left in this slide you can see
a microscopic view of these yeasts from a
tissue section, you can see the individual
cells. And again they are in the very outer
layers of the skin. Most of us are colonized
with Malassezia and we don't even know it,
but occasionally for reasons that are not
yet clear, it causes various syndromes like
Seborrheic dermatitis. This is a pruritic
erythematous, meaning red, patch with greasy
scales. It can happen in your eyebrows, if
you have a mustache it could be there, or
in your beard or it can happen on your scalp.
01:12
This is commonly known as dandruff, that's
right dandruff is caused by a yeast, Malassezia.
01:21
So the next time you have dandruff and you
wear a black shirt, you know, you can see
the flakes on your shoulders, and we are in
today’s society meant to believe that this
is terrible and you should rush to the drugstore
and buy a dandruff shampoo and that's what
many people do, but it can also occur in your
eyebrows, mustache, and beard. So that's one
manifestation of Malassezia. The other is
called Tinea versicolor. These are hypopigmented
or hyperpigmented patches, either over colored
or under colored with a little bit of scaling,
which can be on your chest or your neck. Again
it's from Malassezia, which is normally there,
but something's gone wrong and it causes these
conditions.
02:03
And again you can treat these. Dandruff as
you know, seborrheic dermatitis, which is
the medical name for dandruff, can be treated
with shampoos, special shampoos that have
antifungal agents in them. The tinea versicolor
can be treated with creams that you put on
the afflicted area. These are not life-threatening
infections, but I thought you would like to
know about them, because so many people have
them.
02:31
And here are some of the antifungal agents
that can be used to treat these conditions,
let's zoom in to see how we treat Dermatophytosis,
three different drugs are listed here: Terbinafine,
Ketoconazole, Itraconazole, some of which
are topical, some of which are oral, that's
for dermatophytosis.