Lectures

Major Histocompatibility Complex (MHC) – Antigen Processing and Presentation

by Peter Delves, PhD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides Processing and Presentation of Antigen.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript
    The MHC is the major histocompatibility complex. It’s called that because it’s a complex of genes, it’s not a single gene. And it’s a complex of genes that are the major determinants of tissue compatibility during transplantation. That’s how it was first discovered. When people were exploring, doing skin grafts for example in mice, between different strains of mice, they recognized that the skin graft from a different strain of mouse would be rejected, immunologically rejected due to recognition of these MHC molecules. Well of course, MHC did not evolve to frustrate attempts at transplantation. It’s a consequence of the diversity of the MHC but it’s not why we have an MHC. We have MHC to show protein antigens in the form of peptides to T-cells. In each individual species, the MHC is given a particular name. You only need to really know about two of them. In the human, it’s called HLA. And in the mouse, it’s called H-2. It’s worth knowing that because a lot of immunology is worked out in the mouse. So when you’re reading textbooks and so forth, you may often come across H-2. It’s simply the MHC of the mouse, just like HLA is the MHC of the human. There are two classes of MHC - MHC Class I and MHC Class II. And they are very similar in structure and very similar in what they do as we’ll learn very shortly. There are three types of MHC Class I in the human: HLA-A, HLA-B and HLA-C. And for Class II we have HLA-DP, HLA-DQ and HLA-DR. The MHC Class I molecules are present on all nucleated cells in the body. That’s essentially all cells in the body apart from red blood cells. However, the MHC Class II is only present on a very...

    About the Lecture

    The lecture Major Histocompatibility Complex (MHC) – Antigen Processing and Presentation by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • The Major Histocompatibility Complex
    • The MHC Gene Locus

    Included Quiz Questions

    1. HLA-DR
    2. HLA-A
    3. HLA-B
    4. HLA-C
    5. Factor B
    1. MHC I: Present on all nucleated cells in the body MHC II: Present on professional APCs and thymic epithelium
    2. MHC I: Alerts CD4+ T cells MHC II: Alerts CD8+ T cells
    3. MHC I: Present on RBCs MHC II: Present on professional APCs
    4. MHC I: Binds peptides derived from extracellular antigens MHC II: Binds peptides derived from intracellular antigens
    5. MHC I: Alerts Helper T cells and Regulatory T cells MHC II: Alerts Cytotoxic T cells
    1. C3
    2. Factor B
    3. Lymphotoxin
    4. C4
    5. TNF-alpha

    Author of lecture Major Histocompatibility Complex (MHC) – Antigen Processing and Presentation

     Peter Delves, PhD

    Peter Delves, PhD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0