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Macrolides and Ketolides – Bacterial Protein Synthesis Inhibitors (Antibiotics)
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About the Lecture
The lecture Macrolides and Ketolides – Bacterial Protein Synthesis Inhibitors (Antibiotics) by Pravin Shukle, MD is from the course Antimicrobial Pharmacology. It contains the following chapters:
- Macrolides
- Ketolides
Included Quiz Questions
Which of the following drugs is associated with a prolonged QT interval and inhibition of CYP450 3A4?
- Telithromycin
- Azithromycin
- Clarithromycin
- Erythromycin
- Fidaxomicin
By what mechanism do enterobacteriaceae develop resistance to macrolides?
- Production of drug-destroying esterases.
- Ejector pump mechanism.
- Potentiation of CYP450 enzymes leading to more rapid drug breakdown.
- Development of beta lactamases to break down the drug.
- Adding a methyl group to change the binding site.
Which of the following statements about azithromycin is INCORRECT?
- It is used in clostridium difficile infections.
- It is eliminated slowly.
- It is effective against gonorrhea.
- It has a potent post-antibiotic effect.
- It concentrates in macrophages and tissues.
Author of lecture Macrolides and Ketolides – Bacterial Protein Synthesis Inhibitors (Antibiotics)
Pravin Shukle, MD
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