The secondary lymphoid organs, also called peripheral lymphoid/lymphatic organs, include MALT, the lymph nodes, and the spleen. These collections of lymphoid tissues provide constant surveillance for pathogens. In their distinct sites, these tissues are filled with immune cells ready to mount a response when antigens are detected. Lymph nodes are seen along lymphatic vessels and occur as chains or groups (neck, groin, axillae, mesenteries, abdomen). MALTs act as immune sensors situated in locations where the lumen is exposed to the external environment (oropharynx, GI tract, genitourinary tract). The spleen is the site of production of antibodies and lymphocytes, but it also aids in the breakdown of platelets and erythrocytes.