Trafficking and Homing – Lymphocyte Recirculation and Homing

by Peter Delves, PhD

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    Let’s now look at trafficking to mucosal tissues. Remember, and it’s always really worth remembering this, where do we first encounter pathogens? You may have an abrasion on the skin for example. But actually most pathogens are encountered via mucosal surfaces. You may have a respiratory tract infection, you may have a gastrointestinal tract infection, you may have a sexually transmitted infection. All of these types of pathogens are entering the body via mucosal surfaces. So the immune system spends a lot of time and effort on protecting these very vulnerable mucosal tissues. So in this particular example, we have a infection in the gut. So there is some pathogenic bacteria here in the gut and they are going to invade, and in the Peyer’s patches of the lamina propria, there will be an initiation of an immune response involving the lymphocytes that are present in that location. Following their initial activation, those lymphocytes will migrate via the afferent lymphatics to the local mesenteric lymph nodes. And there further activation will occur. So there’s some preliminary activation within the Peyer’s patch, but then subsequently to get full activation of these lymphocytes, they need to move to the mesenteric lymph nodes. Following their full activation, they will then proliferate and they will differentiate. And subsequently they will leave the mesenteric lymph nodes and travel via the efferent lymphatics, eventually via the thoracic duct rejoining the blood circulation and going back to the lamina propria, which is where the infection was originally located. You have a gastrointestinal tract infection, you’re activating lymphocytes in the GI tract, you’re super-activating them if you’d like in the mesenteric lymph nodes. But those cells and molecules now need to go back to where the infection is. It’s no good them being in the lymph node, they...

    About the Lecture

    The lecture Trafficking and Homing – Lymphocyte Recirculation and Homing by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • Trafficking to Mucosal Tissues
    • Lymphocyte Homing to the Skin
    • Lymphocyte Homing to Peripheral Tissues
    • T-Cell Homing Receptors

    Included Quiz Questions

    1. Mesenteric lymph nodes
    2. Liver
    3. Skin
    4. Spleen
    5. Thymus
    1. ...cells activated in one mucosal area will travel to other mucosal areas - creating a "common mucosal response".
    2. ...activated T cells have an affinity for mucosal surfaces and will travel to these locations first.
    3. ...mucosal tissues drain to lymph nodes in order to generate more active defenses.
    4. ...T cells can more readily access mucosal surfaces to encounter antigens.
    5. ...activated T cells are already present on all mucosal surfaces.
    1. Epidermis
    2. Dermis
    3. Hypodermis
    4. Mucosal lining of GI tract
    5. Mucosal lining of respiratory tract
    1. Cell adhesion molecules specific to different parts of the body which activated T cells can recognize in order to return to the site of infection
    2. Chemokines that signal to T cells to travel to a certain area of the body
    3. Chemokines that signal that vascular damage has occurred due to antigen
    4. Chemokine receptors that activate T cells
    5. Cell adhesion molecules that are unique to the GI tract
    1. CXCR3 and CXCL5
    2. P-selectin ligand and P-selectin
    3. CCR5 and CCL4
    4. LFA-1 and ICAM-1
    5. VLA-4 and VCAM-1

    Author of lecture Trafficking and Homing – Lymphocyte Recirculation and Homing

     Peter Delves, PhD

    Peter Delves, PhD

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