Local Factors of Arterial Pressure – Blood Vessels and Pressure

by Thad Wilson, PhD

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides BloodVesselsAndPressure VascularPhysiology.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    So now let's take a little bit of break from the neurohormonal factors and the vascular anatomy and let's focus on the local factors that control systemic vascular resistance. Because again what are the key points for controlling mean arterial pressure? Cardiac output times systemic vascular resistance. So let's talk about the local factors that affect systemic vascular resistance. In these local factors, there are quite a few, some of them will cause dilation or relaxation of a blood vessel and some will cause constriction of the blood vessel. So a dilation of course is going to open that vessel up and a constriction is going to decrease it. Those two things will change the radius of the blood vessel which then changes its resistance because again radius of the blood vessel is raised to the fourth power and thus is so important for overall resistance. You can see here there's a couple of very important items to think about with the local control of a blood vessel. Probably the most important is the nitric oxide. So NO is an important vasodilatory molecule. The other one that you need to concentrate on is calcium. If calcium decreases in the smooth muscle, that will cause a dilation or vasodilation of the blood vessel. So nitric oxide increases and calcium decreases are the mechanism by which you're going to get a relaxation or a dilation of the blood vessel. Now there are a number of factors that affect either nitric oxide or calcium levels. So let's go through a few of those now. Prostaglandins and endothelial-derived hyperpolarizing factor directly affect calcium levels. Those two items will cause there to be a relaxation because of decrease in calcium levels. Interestingly, even things like shear stress, which is the amount of stress across the...

    About the Lecture

    The lecture Local Factors of Arterial Pressure – Blood Vessels and Pressure by Thad Wilson, PhD is from the course Vascular Physiology.

    Included Quiz Questions

    1. Bradykinin
    2. Angiotensin II
    3. Thromboxane
    4. Increased calcium
    1. Trauma
    2. Shear stress
    3. Bacterial endotoxins
    4. Nitric oxide

    Author of lecture Local Factors of Arterial Pressure – Blood Vessels and Pressure

     Thad Wilson, PhD

    Thad Wilson, PhD

    Customer reviews

    5,0 of 5 stars
    5 Stars
    4 Stars
    3 Stars
    2 Stars
    1  Star