00:01
Let's move on to one of the newer
anti-seizure agents.
00:04
It's called Keppra.
00:05
Now, the the trade name is easier to
pronounce than the generic name, so I'm not
even going to try.
00:11
This is an agent that we think works on a
presynaptic calcium channel that affects the
way, uh, vesicles are released into the
synaptic cleft.
00:23
Keppra is a mostly unknown mechanism of
action.
00:27
It may inhibit the presynaptic calcium
channels, but we're not entirely sure we know
that. It also binds to SV2A, which is a
synaptic vesicle glycoprotein.
00:38
So it may also inhibit the.
00:40
It may also change the way that the vesicle
is being released into the synaptic cleft.
00:47
Side effects of this medication include
sleepiness, which is quite frequent.
00:51
Rarer cases of psychosis and suicide.
00:54
Increased risk can occur with this
medication.
00:57
Rare cases of Stevens-Johnson syndrome have
been reported, and also rare cases of
anaphylaxis can occur with Keppra.
01:05
All of these things do need to be monitored
for.
01:07
Uses include focal epilepsy, partial complex
epilepsy, and generalized epilepsy.
01:15
That's one of the newest agents.
01:17
I hope this information was useful.
01:20
Good luck on your exams.
The lecture Levetiracetam (Keppra) – Antiseizure Medications by Pravin Shukle, MD is from the course CNS - Pharmacology.
What is the most frequent adverse effect of levetiracetam (Keppra)?
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Newer drug great to see some information on it. Excellent lecture series as a whole
correctly pronouncing drugs is important especially when people pay for their education.