Levetiracetam (Keppra) – Antiseizure Medications

by Pravin Shukle, MD

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    00:01 Let’s move on to one of the newer anti-seizure agents, it’s called Keppra.

    00:06 Now the trade name is easier to pronounce than the generic name so I'm not even going to try.

    00:11 This is an agent that we think works on a presynaptic calcium channel that affects the way vesicles are released into the synaptic cleft.

    00:22 Key: 1. AMPA receptor: A type of glutamate receptor that mediates fast synaptic transmission in the central nervous system.

    00:31 2. GABA: Gamma-aminobutyric acid, an inhibitory neurotransmitter that can reduce neuronal excitability.

    00:39 3. Glutamate: The most abundant excitatory neurotransmitter in the central nervous system (CNS).

    00:45 4. KCNQ K+ channel: A type of voltage-gated potassium channel that contributes to stabilizing the electrical activity of neurons. 5. SV2A: Synaptic vesicle glycoprotein 2A, a protein that plays a role in modulating neurotransmitter release. Keppra is a mostly unknown mechanism of action.

    01:08 It may inhibit the presynaptic calcium channels but we're not entirely sure.

    01:12 We know that it also binds to SV2A, which is a synaptic vesicle glycoprotein so it may also inhibit and may also change the way that the vesicle is being released into the synaptic cleft.

    01:28 Side effects of this medication includes sleepiness which is quite frequent.

    01:32 Rarer cases of psychosis and suicide increased risk can occur with this medication.

    01:38 Rare cases of Stevens-Johnsons syndrome have been reported and also rare cases of anaphylaxis can occur with Keppra - all of these things do need to be monitored for.

    01:48 Uses include focal epilepsy, partial complex epilepsy, and generalized epilepsy.

    01:56 That’s one of the newest agents.

    01:58 I hope this information was useful.

    02:01 Good luck on your exams.

    About the Lecture

    The lecture Levetiracetam (Keppra) – Antiseizure Medications by Pravin Shukle, MD is from the course CNS - Pharmacology.

    Included Quiz Questions

    1. Sleepiness
    2. Psychosis
    3. Suicide
    4. Stevens-Johnson syndrome
    5. Anaphylaxis

    Author of lecture Levetiracetam (Keppra) – Antiseizure Medications

     Pravin Shukle, MD

    Pravin Shukle, MD

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    concise explination
    By Kieffer D. on 10. February 2023 for Levetiracetam (Keppra) – Antiseizure Medications

    Newer drug great to see some information on it. Excellent lecture series as a whole

    "im not even going to try"
    By Abdulaziz A. on 17. August 2021 for Levetiracetam (Keppra) – Antiseizure Medications

    correctly pronouncing drugs is important especially when people pay for their education.