00:01 Let’s move on to one of the newer anti-seizure agents, it’s called Keppra. 00:06 Now the trade name is easier to pronounce than the generic name so I'm not even going to try. 00:11 This is an agent that we think works on a presynaptic calcium channel that affects the way vesicles are released into the synaptic cleft. 00:23 Keppra is a mostly unknown mechanism of action. 00:27 It may inhibit the presynaptic calcium channels but we're not entirely sure. 00:32 We know that it also binds to SV2A, which is a synaptic vesicle glycoprotein so it may also inhibit and may also change the way that the vesicle is being released into the synaptic cleft. 00:47 Side effects of this medication includes sleepiness which is quite frequent. 00:51 Rarer cases of psychosis and suicide increased risk can occur with this medication. 00:57 Rare cases of Stevens-Johnsons syndrome have been reported and also rare cases of anaphylaxis can occur with Keppra - all of these things do need to be monitored for. 01:08 Uses include focal epilepsy, partial complex epilepsy, and generalized epilepsy. 01:15 That’s one of the newest agents. 01:17 I hope this information was useful. 01:19 Good luck on your exams.
The lecture Levetiracetam (Keppra) – Anti-Seizure Medications by Pravin Shukle, MD is from the course CNS - Pharmacology.
What is the most frequent adverse effect of levetiracetam?
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Newer drug great to see some information on it. Excellent lecture series as a whole
correctly pronouncing drugs is important especially when people pay for their education.