Large Cell Carcinoma

00:01 Now, we go to another one. This is large cell. This is a little scary. And the reason I say that, you will see. Peripherally located, so now we have two peripherally located.

00:10 The one that is most common. Say that you are running out of time and you have really a peripherally located nodule. One, away from the mediastinum. All you do real quick, is take a look. Well, is this a patient that is a female, is a non-smoker? Adenocarcinoma. I’m sorry, what? Non-smoker, female, peripherally located, adenocarcinoma.

00:31 Go with things that are most common, if you’re running out of time.

00:33 Okay, so with peripherally located nodule. 1: highly anaplastic, undifferentiated. So, that means that it has a really poor prognosis. Is less responsive to chemotherapy, removed surgically. Large anaplastic. Couple of other things here, histology – pleomorphic and may secrete βhCG. You hear a serum test with βhCG, hear about anaplastic. No doubt, peripherally located, large cell. Adenocarcinoma, female, non-smoker, peripherally located, then you know that one. Do not forget about the in-situ please, in adenocarcinoma.