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Large Cell Carcinoma
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Slides PulmonaryNeoplasia RespiratoryPathology.pdf
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Download Lecture Overview
00:01
Now, we go to another one. This is large cell.
This is a little scary. And the reason
I say that, you will see. Peripherally located,
so now we have two peripherally located.
00:10
The one that is most common. Say
that you are running out of time and you
have really a peripherally located nodule.
One, away from the mediastinum. All you do
real quick, is take a look. Well, is this
a patient that is a female, is a non-smoker?
Adenocarcinoma. I’m sorry, what? Non-smoker,
female, peripherally located, adenocarcinoma.
00:31
Go with things that are most common, if you’re
running out of time.
00:33
Okay, so with peripherally located nodule.
1: highly anaplastic, undifferentiated. So,
that means that it has a really poor prognosis.
Is less responsive to chemotherapy, removed
surgically. Large anaplastic. Couple of other
things here, histology – pleomorphic and
may secrete βhCG. You hear
a serum test with βhCG, hear about anaplastic. No doubt,
peripherally located, large cell. Adenocarcinoma,
female, non-smoker, peripherally located, then
you know that one. Do not forget about the
in-situ please, in adenocarcinoma.
About the Lecture
The lecture Large Cell Carcinoma by Carlo Raj, MD is from the course Lung Cancer .
Included Quiz Questions
Which of the following hormones/mediators may be inappropriately secreted in patients with large cell carcinoma?
- Beta-hCG
- ACTH
- ADH
- T4
- PTHrp
What is the first-line treatment for a patient with large cell carcinoma?
- Surgical removal
- Chemotherapy
- Surgical removal followed by chemotherapy
- Radiotherapy followed by chemotherapy
- Radiotherapy
Which of the following findings on histology best describes the appearance of large cell carcinoma?
- Pleomorphic giant cells, highly anaplastic and undifferentiated
- Keratin pearls and intercellular bridges
- Multinucleated giant cells
- Tall columnar cells with intact outer membrane
- Tall columnar cells and mucin+ staining
Author of lecture Large Cell Carcinoma
Carlo Raj, MD
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