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Junctional Diversity, N-Nucleotide Addition and Somatic Hypermutation – Lymphocyte Development

by Peter Delves, PhD
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    About the Lecture

    The lecture Junctional Diversity, N-Nucleotide Addition and Somatic Hypermutation – Lymphocyte Development by Peter Delves, PhD is from the course Adaptive Immune System. It contains the following chapters:

    • Recombinatorial Inaccuracies
    • N-Nucleotide Addition
    • Somatic Hypermutation

    Included Quiz Questions

    1. Alterations in the original blueprint for the light and heavy chains of the immunoglobulin
    2. Variety of amino acid expression
    3. Protein sequences that produce a greater diversity of antibodies
    4. Protein sequences that produce antibodies that are dysfunctional
    5. Different combinations of amino acids from the same germline DNA
    1. Inserts nucleotides into area that has been cut during recombination
    2. Splices DNA back together
    3. Determines where DNA will be cut during D to J recombination
    4. Cuts the DNA in V to D recombination
    5. Recognizing splice junction, allowing enzymes to insert additional nucleotides
    1. Increases affinity for antigens and diversity in antibodies
    2. Decreases affinity for self and increases diversity in antibodies
    3. Increases affinity for antigens and decreases affinity for self
    4. Decreases affinity for antigens and diversity in antibodies
    5. Increases affinity for antigens and decreases diversity in antibodies

    Author of lecture Junctional Diversity, N-Nucleotide Addition and Somatic Hypermutation – Lymphocyte Development

     Peter Delves, PhD

    Peter Delves, PhD


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