00:01
Okay, so you have a patient
with suspected lung
cancer, what are the important questions that
you need to answer. Well the first question
is if it is a lung tumour, which parts of
the body have been affected and that’s called
staging. Secondly you really do need to confirm
whether is it a cancer or not and that
can only be done by obtaining histology and
in addition to that confirming various cancer
if it is a lung cancer, you need to know whether if
it is a small cell. Because that's not treatable
by surgery or non-small cell because that's
potentially treatable by surgery and then
if it is a non-small cell cancer, then the next question
is, has the patient got disease which is localized
that they can afford to have treated
by surgery or by radiotherapy.
00:51
So the staging test we do for patients with
suspected lung cancer. Almost all patients
will have a chest x-ray, a CT over the chest,
the liver and the adrenals and various blood
tests. A chest x-ray is absolutely essential
to make the diagnosis in the first place.
01:12
The CT scan is the only way you can truly assess with
somebody who have hilar and mediastinal
lymph nodes and also tell you whether there
are metastases in the other lung or other
lobes of the same lung. You extend the CT
scan to include the liver and adrenal, so
that it also looks into metastases effecting the
liver and adrenal glands. Both very common
sights of lung cancer metastases. In addition
the CT scan will tell you whether they are
primary tumour, the start cancer, is actually
invading any local tissues. So for example,
if you have a cancer that is invading the
aorta and that precluded from being resected
because surgery would likely to be fatal due
to bleeding.
02:00
The blood tests are used to assess the general
health of the patient but also can give you
a clue about metastatic. So for example, if
you have a raised alkaline phosphatase that
would suggest that they might have liver or
bone metastases. Paraneoplastic syndrome which
as we discussed earlier are also those that are
detectable by measuring the urine electrolytes
and calcium levels etc. Selected patients will
have additional investigations
depending on whether the clinical presentations
suggest that there is metastases present. So for
example, if somebody has palpable nodes in the
neck you do a neck ultrasound to investigate
those in further. If somebody presents
with neurological signs, they will need a
CT scan or MRI of the brain to identify potential
metastases. If it got bone pain or raised
alkaline phosphatase then you might need some
form of bone scan to identify those metastases.
02:48
A spinal MRI and scan will be used for those
presenting with potential vertebral metastases
etc. etc. and clearly a pleural effusion can
easily be tapped to obtain cytology to tell
you whether it is due to cancer of not.
The last test mentioned here is the PET scan.
03:04
This is a radio isotope scan using radioactive
glucose. It is an incredibly useful test for
identifying the potential sites of cancer.
Because with the PET scan what you get is
a total body assessment of where cancer
is larger than 1cm or more maybe. So even
if you don’t suspect somebody has metastases
somewhere a PET scan may identify that.
03:28
Because the radio isotope is concentrated in areas
of tumour. So PET scan is now incresingly becoming a very
essential investigation of a patient who may
be considered of a curative treatment.