Lectures

Insulin – Diabetes Medications

by Pravin Shukle, MD
(1)

Questions about the lecture
My Notes
  • Required.
Save Cancel
    Learning Material 2
    • PDF
      Slides DiabetesMedications EndocrinePharmacology.pdf
    • PDF
      Download Lecture Overview
    Report mistake
    Transcript

    00:01 Welcome to pharmacology by Lecturio. I'm Dr. PJ Shukle and we're going to be talking about drugs in diabetes today.

    00:10 When we talk about drugs and diabetes, let's start off talking about how insulin was discovered.

    00:15 Let's go back to Canada in 1921. There were 4 important individuals which led to the discovery of insulin.

    00:23 The first was Frederick Banting who is a physician studying at the University of Western Ontario.

    00:29 The second, was a man by the name of James Collip, a brilliant biochemist at the University of Alberta.

    00:36 J. J. R. Macleod was a physiologist who is working at the University of Toronto.

    00:41 And finally Charles Best, who was a medical student at the University of Toronto. Now, Charles Best lost the lottery, in terms of which job and which research project he was going to be working for. When he found out that he was going to be working for Frederick Banting in the summer of 1921, he actually tried to give away his research clerkship to somebody else.

    01:05 That other medical student ended up taking a more popular position, relegating him to the ranks of people we don't know anything about. Charles Best then, kind of said okay, I'll work with this guy, we know that he is kind of mean, and mean spirited but I'll work with him. Together they isolated insulin and revolutionized they way we look at diabetes.

    01:28 Prior to 1921, everybody who had diabetes died. These dicoveries would not have happened without James Collip, who is the biochemist, who actually helped them synthesize and isolate this important chemical, this important hormone.

    01:45 So let's talk about insulin and how it works in the body. In the liver, it increases glycogen synthesis and decreases protein catabolism. Now, it uses a porter called GLUT 2 to move sugar into cell membranes.

    02:03 There is increased synthesis using pyruvate kinase, phosphofructokinase and glucokinase.

    02:10 In the skeletal muscle, insulin inreases glycogen synthesis and protein synthesis. And it uses the porter GLUT 4, into the cell membranes. And in the adipose tissue, it increases triglyceride storage and decreases protein catabolism.

    02:26 It uses the porter GLUT 4 and moves most sugar into cell membranes. There is increased synthesis and activity, in adipose tissue under the influence of insulin and we use a hormone called lipoprotein lipase.

    02:43 Now these are things that I want you to remember because these are things that do get put on exams, because insulin is so important, the makers of exams want to make sure that you know, the ins and outs of how it works.


    About the Lecture

    The lecture Insulin – Diabetes Medications by Pravin Shukle, MD is from the course Endocrine Pharmacology. It contains the following chapters:

    • Discovery of Insulin
    • Actions of Insulin

    Included Quiz Questions

    1. In the presence of insulin, skeletal muscle increases glycogen synthesis while adipose tissue increases triglyceride synthesis.
    2. In the presence of insulin, skeletal muscle increases triglyceride synthesis while adipose tissue increases glycogen synthesis.
    3. In the presence of insulin, skeletal muscle decreases glycogen synthesis while adipose tissue increases triglyceride synthesis.
    4. In the presence of insulin, skeletal muscle decreases glycogen synthesis while adipose tissue decreases triglyceride synthesis.
    5. In the presence of insulin, skeletal muscle decreases triglyceride synthesis while adipose tissue also increases triglyceride synthesis.
    1. Glycogen phosphorylase
    2. Pyruvate kinase
    3. Phosphofructokinase
    4. Glucokinase
    5. Lipoprotein lipase

    Author of lecture Insulin – Diabetes Medications

     Pravin Shukle, MD

    Pravin Shukle, MD


    Customer reviews

    (1)
    5,0 of 5 stars
    5 Stars
    5
    4 Stars
    0
    3 Stars
    0
    2 Stars
    0
    1  Star
    0