Important Cells in Chronic Inflammation

by Richard Mitchell, MD, PhD

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    00:01 The cellular players in chronic inflammation include T lymphocytes.

    00:04 These are going to be a source of cytokines, inflammatory mediators that activate other inflammatory cells, and chemokines, things that will recruit cells and activate them.

    00:17 There are B lymphocytes that are part of chronic inflammation, primarily the plasma cells.

    00:23 And they're going to make antibody, and antibody may contribute to chronic inflammation.

    00:27 We won't talk about that so much in this particular set of topics.

    00:32 But we'll revisit this when we talk about immune mediated injury, and another set down the road.

    00:39 You may have other cell types, depending on the mediators that are elaborated, depending on those cytokines.

    00:45 And depending on those chemokines, we may recruit other cells into the mix.

    00:49 And eosinophils, and mast cells are also potentially involved in some forms of chronic inflammation.

    00:57 But the major most important player and it's bigger here, because it's more important are the macrophages.

    01:04 These are going to be sources of cytokines and chemokines.

    01:07 So inflammatory mediators and recruitment molecules.

    01:10 They are also going to be local factories for producing complement, and coagulation factors.

    01:16 They're going to make proteases, Reactive Oxygen Species or ROS, they're going to make eicosanoid.

    01:22 So they're going to make all kinds of important mediators.

    01:25 And importantly, for driving the process of healing and regeneration, they're going to make growth factors.

    01:31 So again, macrophages are the key element, the linchpin for this entire process, and we're going to focus on them.

    01:40 So that's just kind of the overview of where we're going.

    01:42 But we've resolved some of the acute inflammation, And we've recruited and started the process of healing.

    About the Lecture

    The lecture Important Cells in Chronic Inflammation by Richard Mitchell, MD, PhD is from the course Acute and Chronic Inflammation.

    Included Quiz Questions

    1. Production of growth factors
    2. Production of antibodies
    3. Differentiation into memory cells
    4. Production of heparin and histamine
    5. Production of the major basic protein

    Author of lecture Important Cells in Chronic Inflammation

     Richard Mitchell, MD, PhD

    Richard Mitchell, MD, PhD

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