Immune Response

by Peter Delves, PhD

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    00:01 We can divide immune responses into innate responses and adaptive responses.

    00:06 and these have particular characteristics.

    00:08 So, you may be wondering what the difference is between the innate and the adaptive response? Well, I'm going to tell you.

    00:16 Innate immune responses have a very broad specificity for what we call pathogen- associated molecular patterns.

    00:26 deviated to PAMPs, P-A-M-P.

    00:29 Pathogen-associated molecular patterns.

    00:32 This is in contrast to the adaptive immune response, which has a very high degree of specificity for what we refer to as antigen.

    00:41 Antigen is essentially anything that can be recognized by the adaptive immune response.

    00:47 The innate response lacks a type of immunological memory seen in the adaptive response and often exhibits a similar intensity upon re-encounter with the same pathogen.

    01:00 However, in some cases, it may mount an enhanced response when meeting the pathogen again.

    01:07 A phenomenon known as trained innate immunity.

    01:12 We talk about the primary and secondary immune response.

    01:16 This is due to something referred to as immunological memory.

    01:21 And we will learn a lot more about immunological memory later on in these lecture series.

    01:29 And then, finally, the innate immune response is a rapid response.

    01:35 It occurs within minutes or hours.

    01:37 It's very quick.

    01:38 The cells already present in the body tissues, or are recruited directly and very quickly from the blood circulation.

    01:47 So, you can happen very, very soon.

    01:49 In contrast, the adaptive immune response is initially rather slow to get going.

    01:55 It takes a few days before it really gets off the ground and is fully effective.

    02:01 And this is because the cells need to proliferate.

    02:04 They need to expand up in number in the secondary lymphoid tissues.

    02:10 So, on the left hand side here, you can see that the innate immune response cells alive are already in the tissues at the bottom there on the left, you can see a tissue macrophage.

    02:25 Already sitting in the tissues lying in wait, in case an infection comes along.

    02:30 And above that, you can see the multi-lobed neutrophil cell that is leaving a blood vessel and entering to go to the place where the infection is present in the tissues.

    02:45 In contrast, for the adaptive immune response, you need cell proliferation to occur in the secondary lymphoid tissues.

    02:54 As we've already heard, this can take several days to curve fully.

    02:59 And then those cells, once they have proliferated and become activated, can leave the secondary lymphoid tissues, and then themselves go to the location where the infection is present.

    03:13 So one thing that should already be coming quite clear to you actually is that the immune system needs to detect that there is a threat.

    03:22 It needs to recognize the enemy.

    03:25 The immune system is there to attack harmful pathogens.

    03:30 A pathogen, something that generates pathology, something that is going to cause disease.

    03:36 So the immune system needs to be able to detect these harmful pathogens.

    03:43 But there are many things that the immune system should not respond to that we don't want it to respond to.

    03:50 It does not attack our own healthy body components.

    03:54 What? Immunologists refer to as self.

    03:59 Also, we've already mentioned the beneficial commensal microorganisms, or microbiota, as they're often called.

    04:07 These also should not be attacked.

    04:11 Also, food antigens.

    04:13 You probably had something to eat already today.

    04:16 You don't want to attack the antigens that are present in the food and so forth.

    04:20 So there are many things that the immune system should not attack.

    04:24 But there are other things that are harmful, that the immune system does need to mount a response against and eliminate from the body.

    04:33 So how does the immune system actually detect that there's a threat? Well, it has a number of different molecules that we refer to as receptors.

    04:46 And one important group of receptors are the pattern recognition receptors.

    04:52 These are sometimes also referred to as pathogen recognition receptors.

    04:56 I'm afraid as you'll see, there are many alternatives terms that are used in immunology for the same thing.

    05:03 Pattern recognition receptors, pathogen recognition receptors.

    05:07 They both have BVA to PRR.

    05:09 And they both recognize what are referred to as Pathogen-associated molecular patterns or PAMPs.

    05:18 That are molecules that are present either on the surface of pathogens or sometimes inside pathogens.

    05:24 So, pattern recognition receptors recognize pathogen associated molecular patterns in order to determine that there is a threat that needs to be responded to.

    05:38 And the pattern recognition receptor will bind to the pathogen associated molecular pattern.

    05:45 And this will result in a signal being sent into the cell of the immune system, and it will become activated and begin to mount an immune response.

    05:56 As well as recognizing pathogen associated molecular patterns or PAMPs.

    06:01 Pattern recognition receptors can also recognize damage associated molecular patterns.

    06:07 So, maybe you're wondering what's the difference between a DAMP and a PAMP? Well, a DAMP is something that is produced by our own body.

    06:16 These Damage-associated molecular patterns are produced by our own cells, when they become damaged.

    06:23 Whereas, Pathogen-associated molecular patterns as the name indicates, are present either on the surface or within pathogens.

    06:34 And just like the pattern recognition receptors bind to pathogen associated molecular patterns, so, they can bind to the damage-associated molecular patterns.

    06:48 In contrast, the cells of the adaptive immune response have antigen-specific receptors.

    06:55 So, in general, cells the innate response have these pattern recognition receptors.

    07:01 Whereas, the cells of the adaptive immune response have antigen specific receptors.

    07:05 In actual fact, is a little bit more complex than that, because we now know that cells of the adaptive response also have pattern recognition receptors as well as the cells of innate response.

    07:16 That the major way in which cells of the adaptive-response recognize engine is using antigen specific receptors.

    07:26 And they will bind to the pathogen using these receptors, as you can see here.

    About the Lecture

    The lecture Immune Response by Peter Delves, PhD is from the course Immune System: Overview and Cells. It contains the following chapters:

    • The Immune Response
    • How to Recognize the Enemy

    Included Quiz Questions

    1. 2-10 days
    2. 2-3 months
    3. 2-3 weeks
    4. 6-12 hours
    5. 1-6 hours
    1. Innate immune response occurs within hours.
    2. Innate immune response is more specific than adaptive immune response.
    3. Innate immune response is rather slow compared to the adaptive immune response.
    4. Innate immune response mainly originates in the secondary lymphoid tissue.
    1. Pathogen associated molecular patterns (PAMPs) and damage associated molecular patterns (DAMPs)
    2. Only pathogen associated molecular patterns (PAMPs) and specific antigens
    3. Only damage associated molecular patterns (DAMPs) and specific antigens
    4. Only damage associated molecular patterns (DAMPs)
    5. Only specific antigens

    Author of lecture Immune Response

     Peter Delves, PhD

    Peter Delves, PhD

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    Great lecturer!
    By Arjavon T. on 07. September 2020 for Immune Response

    I honestly love this guy's enthusiasm and energy. He definitely comes of as knowledgeable and did a great job at providing an introduction to the immune system (source: M1 student who has already started but not finished studying immunology).

    great lecture!
    By valeriu d. on 05. December 2018 for Immune Response

    Very well organized material, will definitely follow up on this lecture!

    By Güney G. on 13. June 2018 for Immune Response

    For many years, I have read lots of textbooks and lots of lecture slides to learn immunology but it was always confusing and none of them knows how to begin immunology. The immune system is a kind of spider web which has no begin and no end. On the other hand, Dr Delves is a very smart academician who found a way how to chance a spider web into a linear and understandable structure. If you need to learn immunology, don't waste your time beginning with memorizing every immune cell, every receptor. Instead, just leave yourself into the arms of Lecturio by Prof Peter Delves, Lecturio definitely takes you to your goals for sure if your goal related to immunology.

    clear explanation of immunology
    By Shakira S. on 05. December 2017 for Immune Response

    clear and understandable. covered the main aspects of immunology with simple words and attractive pictures. well done!