00:01
Once we've determined
the etiology of our
patients hyperkalemia,
it's going to be important to
make sure that we can
treat them urgently
and expeditiously.
00:09
So there's a couple
of different things
we want to keep in mind.
00:11
Number one.
00:12
We want to potentially
antagonize the membrane effects
of potassium with
calcium if we're
worried about
cardiac dysrhythmias.
00:18
Number two, we can drive
the extracellular
potassium into cells.
00:22
And number three,
we want to remove
that excess potassium
from the body.
00:27
So let's talk a little bit
more about antagonizing
membrane effects of
potassium with calcium.
00:31
This is really only going
to be reserved for patients
who have ECG changes
or an acute rise
in serum potassium.
00:38
And what I want to tell you is
that this does absolutely
nothing for removing potassium.
00:42
This is only to protect
cardiac myocytes.
00:47
We can use calcium chloride
or calcium gluconate,
and the mechanism
and when we think about
in terms of what happens
hyperkalemia induces
the depolarization
of the resting
membrane potential,
that leads to inactivation
of the sodium channels
in a decreased
membrane excitability.
01:01
So calcium antagonizes
this membrane affect.
01:04
The mechanism is
not well understood.
01:07
But again, what I want to
underscore here is that
this is to protect
cardiac myocytes.
01:11
It does nothing
in efforts to remove excess
potassium from the body.
01:16
So the next thing we
want to think about
in terms of the treatment
of hyperkalemia,
and what we have in
our armamentarium
is driving the extracellular
potassium into cells.
01:25
So we can do this
by using insulin.
01:28
So remember what insulin does
it's going to cause
uptake of potassium
into the cell by
stimulating the activity
of the sodium-potassium ATPase.
01:35
Now if we're going to give this
as a therapy for hyperkalemia,
it's going to be important
to give it with glucose
if our patients are
normal glycemic.
01:43
We can also use beta-2 agonists
like Albuterol and terbutaline.
01:46
This also stimulates the
sodium-potassium ATPase,
but it does so through
a different mechanism
than insulin.
01:53
It actually works
through cyclic-AMP.
01:55
Therefore when you use beta
agonists along with insulin,
it provides a
synergistic effect,
and it can actually
lower potassium
by about 1.2 to 1.5 milli
equivalents when used together.
02:08
So finally,
we're left with our last category,
which is removing excess
potassium from the body.
02:14
There's a couple of different
ways that we can do this.
02:17
Number one is diuretics.
02:18
Remember Loop Diuretics
and thiazide diuretics.
02:21
We said by that
mechanism of an increase
in distal delivery of sodium
mediates potassium e-flux
into that tubular fluid.
02:28
We can use these
therapies in patients
who are relatively stable
and long-term out patients
who have chronic kidney disease.
02:36
Loop Diuretics can also be
effective in the short term
when combined with
saline to maintain
that distal delivery of sodium
and distal tubular flow,
but we rarely do this.
02:46
Another mechanism for
potassium removal include
using cation exchange resins.
02:52
This includes sodium
polystyrene sulfonate
otherwise known as kayexalate.
02:56
This is an exchange resin
that will take a potassium
in the gut and release sodium.
03:01
Now most preparations
that are used are
prepared using sorbitol.
03:04
That's an osmotic laxative
which we'll also
add to the mechanism
of potassium excretion.
03:10
But what you need
to keep in mind is
that that's orbital
component can actually lead
to intestinal necrosis.
03:15
So we have to be very careful
about using this medication
certainly in our surgical
patients who are at highest risk.
03:22
There are other cation
exchange resins available too.
03:25
Paitromir,
also known as Veltessa.
03:27
This takes up potassium
and exchange for
calcium in the colon.
03:32
And likely,
in the long term this will replace
sodium polystyrene sulfonate.
03:36
Another one that's
new to the market
is zirconium cyclosilicate.
03:40
And this is something that
will exchange both sodium
and protons for potassium
during the intestinal transit.
03:46
Again, this will likely
replace sodium polystyrene
sulfonate in the long term.
03:51
Finally when we're thinking
about potassium removal,
probably the most effective way
of moving potassium urgently
is through dialysis.
04:00
And this is warranted
when the prior mechanisms
or measures are insufficient
to correct the hyperkalemia.
04:06
Or if for example,
somebody is expected to
have a massive increase
in potassium released either
because of rhabdomyolysis
or tissue breakdown.
04:15
Hemodialysis is going to
be the preferred modality
because it can remove up to
about 25 to 50 Milli equivalents
of potassium per hour.
04:23
And it's certainly the treatment
of choice in our patients
who have end-stage
renal disease.
04:28
We also want to think about
treating reversible causes.
04:31
So if a patient is on a drug,
that's causing hyperkalemia.
04:35
We want to discontinue
that drug.
04:36
And finally in our patients
who are volume depleted,
we want a volume expand them
so that we can increase that
distal delivery of sodium.