Let's talk about hormone binding proteins.
Now, before we begin this topic,
hormone binding proteins,
all of these are coming from where?
Liver, liver, liver, liver.
How are the boards going to
ask you about this?
They'll talk to you about
pregnancy, one thing.
tell me what is the major circulating
hormone that is found.
what can you expect your
binding protein concentration to be?
So, estrogen works in the liver
to increase your binding proteins.
We'll take a look at
the table down below.
Begin at the very top.
Sex hormone binding globulin.
These are called globulins.
In other words,
these are proteins.
Coming from where?
What's your hormone responsible for
increasing your binding globulin?
Sex hormone binding globulin will
bind to estrogen and testosterone.
Now, before I go on,
there is one point that
students keep mistaking here
and they get androgen binding globulin
confused with sex hormone binding globulin.
The androgen-binding globulin,
let’s talk about the testes,
I want you tell me what
the inner cell of a testes is called.
That also has a binding globulin.
That’s not the same one as this.
That’s where students keep confusing this.
So, you have an androgen binding globulin
that locally binds your
androgen within your Sertoli cell.
Keep that that separate from
your sex hormone binding globulin.
I’m going to give you a second example
where students keep getting this confused as well.
It’s a concept.
What about the next one?
It’s called cortico-binding hormone.
In other words,
cortisol binding hormone.
Neurophysins, where are you?
The neurophysins actually would be
up in the hypothalamus
responsible for binding your
posterior pituitary hormones.
Take a look at vasopressin,
That’s all that I wish
to say about that.
Now, this is the other one here.
here’s it’s the liver,
estrogen will up-regulate
That is a huge topic for us.
But do not confuse this
with in the thyroid gland.
What is it that actually
attaches to T3, T4?
What attaches to T3, T4
and brings it into the colloid?
Of a thyroid follicular epithelial cell
into the colloid
is called your thyroglobulin.
Do not confuse the thyroglobulin,
which is important clinically,
especially if you are using it to,
such as papillary cancer
thyroid or Hashimoto.
Then do not confuse that
with our binding globulin,
which is being released from the liver.
Then you have IGF-binding protein
and you also have something
called vitamin D binding proteins.
Take a look at all of these.
All of these particular hormones are pretty much,
well, lipid soluble,
They’re all lipid soluble.
They need to have a binding globulin,
so that you properly chaperone
them in your circulation.