HIV (Human Immunodeficiency Virus)

by Carlo Raj, MD

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    Now, we have CNS infection being caused by HIV. We call this aseptic meningitis. Aseptic. It’s a virus. One to two weeks of seroconversion in about 10%. Now, what about HIV? Now, this is a big topic, isn’t it? So from microbiology, we have plenty, plenty of questions that are always being bombarded to you on HIV. And once you’re in that immunocompromised state, there are all kinds of issues that might take place either in a form of microbiology, or with cancers. Invasion of the nervous system has been shown to be mild lymphocytic meningitis. We could have perivascular type of inflammation and some myelin loss. Let’s talk about HIV meningoencephalitis. Dementia, ataxia, incontinence, and seizures. At first, we have vacuolar myelopathy found in AIDS patient. What happened? Microscopically resembles subacute, combined degeneration. Remember vitamin B12 deficiency and subacute combined. What do you mean by combined? You could have issues with the dorsal column. So you have problems with touch, vibration and proprioception. You could have your lateral corticospinal tract being affected. And of course, your spinal cerebellar resulting in ataxia. Keep that in mind with AIDS patient, who behaves like your B12-deficient subacute combined degeneration. AIDS-associated peripheral neuropathy. Demyelinating polyneuropathy. Distal symmetric. Polyradiculopathy, and mononeuritis multiplex with AIDS. Basically, you have multiple, multiple nerves that are being affected undergoing severe neuropathy. Peripheral, peripheral. So we have vacuolar myelopathy and we have AIDS-associated peripheral neuropathies. You’ve been with me long enough to know that whatever that I give you has to be properly integrated. You’ve been with me long enough where I’m always, always reinforcing organization and what the big picture is. The reason that I bring this to your attention and you also had been with me long enough where I’m always giving you the clinical picture of...

    About the Lecture

    The lecture HIV (Human Immunodeficiency Virus) by Carlo Raj, MD is from the course CNS Infection—Clinical Neurology.

    Included Quiz Questions

    1. Granulomas
    2. Nemaline rods
    3. Interstitial infiltration of HIV positive macrophages
    4. Muscle fiber necrosis
    5. Cytoplasmic rods
    1. Gullian Barre syndrome
    2. Inflammatory demyelinating polyneuropathy
    3. Distal symmetric polyneuropathy
    4. Polyradiculopathy
    5. Mononeuritis multiplex
    1. Ragged red fibers myopathy
    2. Nemaline rod myopathy
    3. central core myopathy
    4. inflammatory myopathy
    5. centronuclear myopathy

    Author of lecture HIV (Human Immunodeficiency Virus)

     Carlo Raj, MD

    Carlo Raj, MD

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