Herpes Simplex Encephalitis: HSV-1 and HSV-2

by Carlo Raj, MD

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    Our topic is herpes simplex encephalitis. But here, we’re dealing with HSV-1. What we’ll do here is divide HSV-1 and HSV-2 and then, I will highlight to you what parts of the brain are being affected with either type of viral infection. This must be black and white for you. Otherwise, a clinical presentation on your boards or in clinical practice is going to be difficult and if you miss it, I am going to be very upset. Most commonly in children, young adult. That’s why I’ll be upset. Most common in children, in young adults. What parts of the brain will be affected? You should know that it’s the frontal and temporal lobe. As soon as you hear about frontal lobe, then what kind of issues or what kind of activity are you thinking about? M and M. Mood and memory. Seizures could also be a possibility because we have encephalitis, which then behaves as a space-occupying lesion. Now, HSV-1 in terms of pathology, once again, please make sure that you’re familiar with what parts of the brain? The temporal and frontal. You focus on that. Here, the brain is undergoing such extensive damage, that we have necrotization and we have often hemorrhagic, dangerous. As soon as you hear about HSV-1 or herpes in general, you should be thinking about Tzanck and then what kind of inclusion bodies? Cowdry. And in the CSF, you should be thinking about PCR, polymerase chain reaction, as being the most accurate diagnostic procedure. This is HSV-1. Now, with HSV-1, we have a child that’s being affected. Do not waste time. You get a history and you suspect there is mood and memory and such that’s taking place. And now, at this point, treatment. You begin IV acyclovir as soon as possible. Do not...

    About the Lecture

    The lecture Herpes Simplex Encephalitis: HSV-1 and HSV-2 by Carlo Raj, MD is from the course CNS Infection—Clinical Neurology. It contains the following chapters:

    • Herpes Simplex Encephalitis: HSV-1
    • Herpes Simplex Encephalitis: HSV-2
    • Acute Viral Meningitis: CSF Findings
    • Progressive Multifocal Leukoencephalopathy
    • Varicella Zoster Virus (Herpes Zoster)

    Included Quiz Questions

    1. 15 years to 35 years
    2. Less than 1 month old
    3. Between 1 month to 2 years
    4. Between 40 years to 60 years
    5. More than 60 years old
    1. Orbital gyrus of frontal lobe
    2. Middle temporal gyrus of temporal lobe
    3. Angular gyrus of parietal lobe
    4. Lateral occipital gyrus of occipital lobe
    5. Pituitary gland
    1. Cowdry bodies type A bodies
    2. Negri bodies
    3. Molluscum bodies
    4. Henderson Patterson bodies
    5. Cowdry type B bodies
    1. CSF HSV PCR
    2. CSF cell counts
    3. CSF protein
    4. CSF glucose
    5. Clinical diagnosis
    1. HSV 2
    2. HSV 1
    3. St. Louis virus
    4. Neisseria meningitidis
    5. Borrelia burgdorferi
    1. Oligodendrocytes
    2. Microglia
    3. Astrocytes
    4. Ependymal cells
    5. Peripheral nerve cells
    1. Herpes Zoster
    2. Herpes Simplex virus 1
    3. Herpes Simplex virus 2
    4. Borrelia Burgdorferi
    5. St. Louis virus

    Author of lecture Herpes Simplex Encephalitis: HSV-1 and HSV-2

     Carlo Raj, MD

    Carlo Raj, MD

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